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天然乳化剂阿拉伯胶对绿原酸自微乳体内外性能的影响
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| 篇名： | 天然乳化剂阿拉伯胶对绿原酸自微乳体内外性能的影响 |
| TITLE： | |
| 摘要： | 目的：研究天然乳化剂阿拉伯胶对绿原酸自微乳体内外性能的影响。方法：以阿拉伯胶逐步取代含非离子型乳化剂的绿原酸自微乳（简称“传统绿原酸自微乳”）中的聚山梨酯80制成含阿拉伯胶的绿原酸自微乳（简称“新型绿原酸自微乳”），评价两种自微乳的外观、乳滴形态、粒径、电导率、pH值、稳定性、体外释放度和肠吸收动力学指标。结果：新型绿原酸自微乳采用阿拉伯胶取代了聚山梨酯80处方量的50％。传统和新型绿原酸自微乳的微乳液外观澄明，乳滴为近似球形，粒径分别为（24.53±3.03）、（35.51±5.91） nm，电导率分别为（195.6±0.3）、（189.5±0.4） μs/cm，pH分别为3.87±0.02、4.08±0.03（n＝3）。与传统绿原酸自微乳比较，新型绿原酸自微乳在十二指肠、空肠、回肠中的吸收速率常数、有效渗透系数和吸收量均略有增加（P＞0.05），在结肠中的上述指标均明显降低（P＜0.05）。结论：新型绿原酸自微乳可保持传统绿原酸自微乳的性能，并能增加绿原酸在小肠的吸收。 |
| ABSTRACT： | OBJECTIVE： To study the effect of natural emulsifier acacia senegal on in vivo and in vitro performance of chlorogenic acid self-microemulsion. METHODS： Chlorogenic acid self-microemulsion containing acacia senegal （“new chlorogenic acid self-microemulsion”） was prepared by using acacia senegal to gradually replace polysorbate 80 in chlorogenic acid self-microemulsion containing nonionic emulsifier （“traditional chlorogenic acid self-microemulsion”）. The appearance， morphology， particle size， conductivity， pH value， stability， in vitro release and intestinal absorption kinetics of the 2 kinds self-microemulsions were evaluated. RESULTS： 50％ of polysorbate 80 was replaced by acacia senegal in new chlorogenic acid self-microemulsion. The traditional and new chlorogenic acid self-microemulsions had clear appearance， and approximately spherical drops. Particle sizes were （24.53±3.03）， （35.51±5.91） nm； dectrical conductivities were （195.6±0.3）， （189.5±0.4） μs/cm； and pH were 3.87±0.02， 4.08±0.03 （n＝3）， respectively. Compared with traditional chlorogenic acid self-microemulsion， the absorption rate constant， effective permeability coefficient and absorption amount of the new one in duodenum， jejunum， ileum were increased a little （P＞0.05）； the above indexes in colon were obviously decreased （P＜0.05）. CONCLUSIONS： The new chlorogenic acid self-microemulsion can maintain the performance of traditional one， and increase absorption of chlorogenic acid in small intestine. |
| 期刊： | 2017年第28卷第25期 |
| 作者： | 陈莉，侯成贤，杨燕飞 |
| AUTHORS： | CHEN Li，HOU Chengxian，YANG Yanfei |
| 关键字： | 阿拉伯胶；绿原酸；自微乳；粒径；体外释放度 |
| KEYWORDS： | Acacia senegal； Chlorogenic acid； Self-microemulsion； Particle size； in vitro release |
| 阅读数： | 252 次 |
| 本月下载数： | 2 次 |
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