南京地区31家医院2013-2015年抗抑郁药使用分析
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篇名: 南京地区31家医院2013-2015年抗抑郁药使用分析
TITLE:
摘要: 目的:为抗抑郁药的临床合理使用提供参考。方法: 采用回顾性研究方法,对南京地区31家医院2013-2015年抗抑郁药的销售金额、用药频度(DDDs)、日均费用(DDC)、序号比(B/A)等进行统计分析。结果:南京地区31家医院共涉及20种抗抑郁药,总销售金额呈逐年增长趋势,由2013年的7 608.52万元增长至2015年的10 081.25 万元,2014年和2015年分别较上一年增长17.43%和12.83%;帕罗西汀、艾司西酞普兰、舍曲林和文拉法辛的销售金额和DDDs每年均排在前4位,且四者的销售金额之和占总销售金额的60%以上;植物类抗抑郁药的销售金额增长较快。各年度抗抑郁药的B/A及DDC值与上年度比较均相对稳定,其中,多虑平、氯米帕明和阿米替林的 DDC值<2 元,舍曲林、氟伏沙明、氟哌噻吨美利曲辛、多虑平、氯米帕明和阿米替林的B/A值>1.00。结论: 南京地区31家医院2013-2015年临床使用的抗抑郁药中, 选择性 5-羟色胺再摄取抑制剂、5-羟色胺和去甲肾上腺素能再摄取抑制剂占主导地位,植物类抗抑郁药前景可观。
ABSTRACT: OBJECTIVE: To provide reference for rational use of antidepressive drugs. METHODS: In retrospective study, the utilization of antidepressive drugs in 31 hospitals of Nanjing area during 2013-2015 was analyzed statistically in respects of consumption sum, DDDs, DDC, B/A, etc. RESULTS: There were a total of 20 kinds of antidepressive drugs in 31 hospitals of Nanjing area, and total consumption sum increased year by year, increasing from 76 085 200 yuan in 2013 to 100 812 500 yuan in 2015, increased by 17.43% compared to 2014 and by 12.83% compared to 2015. The top 4 drugs in the list of consumption sum and DDDs were paroxetine, escitalopram, sertraline and venlafaxine. The sum of their consumption sum accounted for more than 60% of total consumption sum. The consumption sum of plant antidepressive drugs increased rapidly. B/A and DDC of antidepressive drugs kept stable each year compared to last year, among which DDC of doxepin, clomipramine and amitriptyline was less than 2 yuan, B/A values of sertraline, fluvoxamine, flupentixol and melitracen, doxepin, clomipramine and amitriptyline were all more than 1.00. CONCLUSIONS: Of antidepressive drugs in 31 hospitals of Nanjing area during 2013-2015, selective serotonin reuptake inhibitors and selective serotonin-norepinephrine reuptake inhibitors took up dominant place, and plant antidepressive drugs is promising in the future.
期刊: 2016年第27卷第35期
作者: 潘海燕,刘慧,许静洁,王甲
AUTHORS: PAN Haiyan,LIU Hui,XU Jingjie,WANG Jia
关键字: 抗抑郁药;销售金额;用药频度;用药分析;南京
KEYWORDS: Antidepressive drugs; Consumption sum; DDDs; Analysis of drug use; Nanjing
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