益气活血风静胶囊对麻醉犬脑血流量和脑血管阻力的影响
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篇名: 益气活血风静胶囊对麻醉犬脑血流量和脑血管阻力的影响
TITLE:
摘要: 目的:研究益气活血风静胶囊对麻醉犬脑血流量(CBF)及脑血管阻力(CVR)的影响,为其临床应用提供药理学依据。方法:将18只Beagle犬随机分为假手术组(纯化水)、阳性对照中药组[脑心通胶囊,0.3 g(生药)/kg]、阳性对照化学药组(尼莫地平,7×10-3 g/kg)和益气活血风静胶囊高、中、低剂量组[2.52、1.26、0.63 g(生药)/kg)],每组3只。犬麻醉后十二指肠给药,分别于给药前和给药30、60、120 min后测定血压、心率和CBF、CVR的变化。结果:给药30、60、120 min后,阳性对照中药组、阳性对照化学药组和益气活血风静胶囊高剂量组犬CBF明显增加,阳性对照化学药组和益气活血风静胶囊高剂量组犬CVR明显减小,阳性对照化学药组犬血压和心率降低,与假手术组比较差异均有统计学意义(P<0.05或P<0.01)。结论:益气活血风静胶囊可减小麻醉犬CVR、增加CBF,对血压及心率无影响。
ABSTRACT: OBJECTIVE: To observe the effects of Yiqi huoxue fengjing capsules on the cerebral blood flow (CBF) and cerebral vascular resistance (CVR) in anesthetized dogs. METHODS: 18 Beagle dogs were randomly divided into sham operation group (purified water), positive control TCM group [Naoxintong capsules, 0.3 g(crude drug)/kg], positive control pharmaceutical chemicals group (nimodipine, 7×10-3 g/kg) and Yiqi huoxue fengjing capsules low-dose, medium-dose and high-dose groups [0.63, 1.26, 2.52 g(crude drug)/kg)], with 3 dogs in each group. They were given relevant medicine via duodenum. CBF, CVR, blood pressure and heart rate of the dogs were measured before medication and 30, 60, 120 min after medication. RESULTS: 30, 60, 120 min after medication, CBF increased in positive control TCM group, positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsule high-dose group, while CVR decreased significantly in positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsules high-dose group, blood pressure and heart rate of positive control pharmaceutical chemicals group decreased, with statistical significance compared to sham operation group (P<0.05 or P<0.01). CONCLUSIONS: Yiqi huoxue fengjing capsules can increase CBF and decrease CVR, and they have no effect on blood pressure and heart rate in anesthetized dogs.
期刊: 2016年27卷第34期
作者: 张军霞,林红军,张婷婷,陈炜,李振国,周继春
AUTHORS: ZHANG Junxia,LIN Hongjun,ZHANG Tingting,CHEN Wei,LI Zhenguo,ZHOU Jichun
关键字: 益气活血风静胶囊;脑血流量;脑血管阻力;Beagle犬
KEYWORDS: Yiqi huoxue fengjing capsules; Cerebral blood flow; Cerebral vascular resistance; Beagle dog
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