临床药师参与化脓性脑膜炎患者抗感染治疗分析
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篇名: 临床药师参与化脓性脑膜炎患者抗感染治疗分析
TITLE:
摘要: 目的:为临床药师参与化脓性脑膜炎患者抗感染治疗提供参考。方法:回顾性分析了2010年1月-2015年12月我院临床药师参与会诊、且初始抗感染治疗效果不佳的26例化脓性脑膜炎出院患者的病历资料,对其病原菌检出情况、初始抗感染治疗方案、临床药师会诊意见和患者转归等情况进行归纳和总结。结果:26例化脓性脑膜炎患者中,共检出病原菌26株,主要包括肺炎链球菌(7株)、金黄色葡萄球菌(5株)、李斯特菌(4株)、铜绿假单胞菌(4株)和鲍曼不动杆菌(2株)等;初始抗感染治疗方案存在未覆盖病原菌(11例,42.31%)、抗菌药物剂量和频次不合理(5例,19.23%)、联合用药不合理(3例,11.54%)、药物选择不合理(3例,11.56%)、疗程不合理(2例,7.69%)和给药途径不合理(2例,7.69%)等情况。临床药师参与会诊后,针对性提出了联合使用其他抗菌药物(10例,38.46%)、调整抗菌药物品种(7例,26.92%)、调整剂量和(或)频次(5例,19.23%)、改变给药途径(2例,7.69%)等会诊意见。经用药调整后,有22例患者病情好转(格拉斯哥评分5分)。结论:临床药师利用自身专业知识,分析患者病原菌情况,并通过会诊协助医师调整和完善化脓性脑膜炎患者的抗感染治疗方案,促进了初始抗感染治疗效果欠佳患者的病情转归。
ABSTRACT: OBJECTIVE: To provide reference for clinical pharmacists participating in anti-infection treatment for patients with purulent meningitis. METHODS: Medical records of 26 discharged patients with purulent meningitis in our hospital during Jan. 2010 to Dec. 2015 were analyzed retrospectively, the consultation of which clinical pharmacists participated in and which showed poor therapeutic efficacy. The data was summarized in respects of pathogen detection, preliminary anti-infection plan, consultation advice of clinical pharmacists, outcome, etc. RESULTS: Among 26 cases, 26 strains of pathogen were detected, mainly including Streptococcus pneumoniae  (7 strains), Staphylococcus aureus  (5 strains), Listeria monocytogenes  (4 strains), Pseudomonas aeruginosa  (4 strains) and Acinetobacter baumannii  (2 strains). There were many problems in preliminary anti-infection plan, such as not cover pathogen (11 cases, 42.31%), irrational dosage and frequency of antibiotics (5 cases, 19.23%), irrational drug combination (3 cases, 11.54%), irrational drug selection (3 cases, 11.54%), irrational treatment course (2 cases, 7.69%) and irrational route of administration (2 cases, 7.69%). Clinical pharmacists provided consultation advise, such as combined with other antibiotics (10 cases, 38.46%), adjusting the types of antibiotics (7 cases, 26.92%), adjusting dosage and (or) frequency (5 cases, 19.23%), changing route of administration (2 cases, 7.69%), etc. After medication adjustment, 22 patients were recovered (Glasgow score of 5 points). CONCLUSIONS: Clinical pharmacists analyze the pathogen by their professional knowledge, assist physicians to adjust and improve anti-infection plan for patients with purulent meningitis through consultation, and promote the clinical outcome of patients with poor efficacy after preliminary anti-infection treatment.
期刊: 2016年第27卷第32期
作者: 王海涛,张抗怀,刘娜,王娜,蔡艳,张莉
AUTHORS: WANG Haitao,ZHANG Kanghuai,LIU Na,WANG Na,CAI Yan,ZHANG Li
关键字: 化脓性脑膜炎;抗感染治疗;回顾性分析;临床药师;病原菌;会诊
KEYWORDS: Purulent meningitis; Anti-infection treatment; Retrospective analysis; Clinical pharmacist; Pathogen; Consultation
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