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百令胶囊辅助治疗过敏性紫癜肾炎患儿的临床观察
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| 篇名： | 百令胶囊辅助治疗过敏性紫癜肾炎患儿的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察百令胶囊辅助治疗过敏性紫癜肾炎（HSPN）患儿的临床疗效及安全性。方法：按照入院先后顺序将本院收治的97例HSPN患儿分为观察组（48例）和常规组（49例）。常规组患儿给予苯那普利2.5～5 mg，qd，血尿合并蛋白尿及急性肾炎型加用吗替麦考酚酯15～20 mg/kg，bid或强的松0.5～1 mg/（kg·d）。观察组患儿在常规组基础上加用百令胶囊0.5～1.0 g，tid。两组患儿均连续治疗4周以上。观察两组患儿治疗后临床疗效及治疗前后血清炎性因子水平[白细胞介素（IL）-6、IL-10、IL-18、肿瘤坏死因子α（TNF-α）]、外周血细胞免疫水平（CD3+、CD4+、CD8+、CD4+/CD8+）和体液免疫水平[免疫球蛋白（Ig）M、IgA、IgG]，并比较两组患儿不良反应发生情况。结果：观察组患儿临床总有效率75.00％，显著高于常规组的55.10％，差异有统计学意义（P＜0.05）。治疗前，两组患儿血清炎性因子水平、外周血细胞免疫水平和体液免疫水平比较，差异无统计学意义（P＞0.05）；治疗后，两组患儿IL-6、IL-18、TNF-α及IgM、IgA、IgG水平显著降低，IL-10、CD3+、CD4+/CD8+水平显著升高，且观察组显著优于对照组，差异均有统计学意义（P＜0.05）。两组患儿不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：百令胶囊辅助治疗HSPN非肾病型患儿能够显著提高临床疗效，改善患儿免疫水平，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of Bailing capsules in adjunctive treatment of children of henoch-schonlein purpura nephritis. METHODS： 97 non-nephrotic syndrome type of HSPN children with admitted in our hospital were divided into observation group （48 cases） and routine group （49 cases） according to admission order. Routine group was given benazepril 2.5-5 mg， qd， and the children with hematuresis compliacting with albuminuria and acute nephritis additionally received mycophenolate mofetil 15-20 mg/kg， bid or prednisone 0.5-1 mg/（kg·d）. Observation group was additionally given Bailing capsule 0.5-1.0 g，tid， on the basis of routine group. Both groups received treatment for more than 4 weeks. Clinical efficacy of 2 groups were observed after treatment as well as the levels of serum inflammatory factors （IL-6， IL-10， IL-18， TNF-α）， peripheral blood cell immune level （CD3+， CD4+， CD8+， CD4+/CD8+）， body fluid immune level （IgM， IgA， IgG） before and after treatment. The occurrence of ADR was compared. RESULTS： The markedly effective rate of observation group was 75.00％， which was significantly higher than 55.10％ of routine group （P＜0.05）. There was no statistical significance in serum inflammatory factor， peripheral blood cell immune level and body fluid immune level （IgM，IgA，IgG） before treatment （P＞0.05）. After treatment， the levels of IL-6， IL-18， TNF-α， IgM， IgA and IgG of 2 groups were decreased significantly， while the levels of IL-10， CD3+ and CD4+/CD8+ were increased significantly； the observation group was significantly better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： For adjunctive treatment of non-nephrotic syndrome type of HSPN， Bailing capsule can significantly improve clinical efficacy and immune level with good safety. |
| 期刊： | 2016年第27卷第32期 |
| 作者： | 厉洪江，刘翠华，田明，吴丽娟，张书锋，曹广海，张雪丽 |
| AUTHORS： | LI Hongjiang，LIU Cuihua，TIAN Ming，WU Lijuan，ZHANG Shufeng，CAO Guanghai，ZHANG Xueli |
| 关键字： | 百令胶囊；过敏性紫癜肾炎；免疫功能；炎性因子；临床疗效 |
| KEYWORDS： | Bailing capsule； Henoch-Schonlein purpura nephritis； Immune function； Inflammatory factor； Clinical efficacy |
| 阅读数： | 347 次 |
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