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溴芬酸钠滴眼液治疗干眼症的临床观察
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| 篇名： | 溴芬酸钠滴眼液治疗干眼症的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察溴芬酸钠滴眼液治疗干眼症的临床疗效及安全性。方法：将80例干眼症患者按随机数字表法分为对照组和观察组，各40例。对照组患者给予0.1％浓度的玻璃酸钠滴眼液1滴，qd；观察组患者给予0.1％的溴芬酸钠滴眼液1滴，bid。两组患者均治疗14 d。观察两组患者治疗前及治疗后3、7、14 d自觉症状和体征、泪膜破裂时间及荧光素染色评分，采用泪液分泌试验（schimer）测量泪液分泌量，并比较两组患者临床疗效及不良反应发生情况。结果：治疗前及治疗后3、7 d，两组患者自觉症状和体征、泪膜破裂时间、荧光素染色评分及泪液分泌量比较，差异均无统计学意义（P＞0.05）；治疗后14 d，两组患者自觉症状和体征、荧光素染色评分显著降低，泪膜破裂时间显著延长，泪液分泌量明显增加，且观察组明显优于对照组，差异均有统计学意义（P＜0.05）。观察组患者治愈率为60.0％，显著高于对照组的35.0％，差异有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：溴芬酸钠滴眼液治疗干眼症疗效显著，能够有效缓解患者干眼症状，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of Bromfenac sodium eyed drops in the treatment of xerophthalmia. METHODS： 80 patients with xerophthalmia were randomly divided into observation group and control group， with 40 cases in each group. Control group was given 0.1％ Sodium hyaluronate， one drop， qd； observation group was given 0.1％ Sodium hyaluronate eye drops， one drop， bid. Both groups received 14 d of treatment. The subjective symptom and sign， the time of lacrimal film break-up， fluorescent staining score and schemer test were observed in 2 groups before treatment， 3， 7， 14 d after treatment. Clinical efficacy and the occurrence of ADR were observed in 2 groups. RESULTS： There was no statistical significance in subjective symptom and sign， the time of lacrimal film break-up， fluorescent staining score and tear between 2 groups before treatment， 3， 7 d after treatment （P＞0.05）. 14 d after treatment， subjective symptom and sign and fluorescent staining score of 2 groups were decreased significantly， and the time of lacrimal film break-up was prolonged and secretion was increased significantly； the observation group was significantly better than the control group， with statistical significance （P＜0.05）. The cure rate of observation group was 60.0％， which was significantly higher than that of control group （35.0％）， with statistical significance （P＜0.05）. There were no statistical significance in ADR between 2 groups （P＞0.05）. CONCLUSIONS： Sodium hyaluronate eye drops is effective for xerophthalmia， and can relieve the symptoms with good safety. |
| 期刊： | 2016年第27卷第29期 |
| 作者： | 庞彦英，韩艳飞，代淑静，韩二杰，杨云东 |
| AUTHORS： | PANG Yanying，HAN Yanfei，DAI Shujing，HAN Erjie，YANG Yundong |
| 关键字： | 溴芬酸钠滴眼液；干眼症；玻璃酸钠；泪膜破裂；泪液分泌试验；疗效 |
| KEYWORDS： | Bromfenac sodium eye drop； Xerophthalmia； Sodium hyaluronate； Lacrimal film break-up； Schemer test； Efficacy |
| 阅读数： | 479 次 |
| 本月下载数： | 2 次 |
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