注射用阿奇霉素致儿童不良反应危险因素分析
x

请在关注微信后,向客服人员索取文件

篇名: 注射用阿奇霉素致儿童不良反应危险因素分析
TITLE:
摘要: 目的:探讨注射用阿奇霉素致儿童不良反应的危险因素。方法:回顾性收集428例静脉注射用阿奇霉素的患儿资料、用药情况,并采用Logistic回归方法对可能发生不良反应的危险因素进行分析。结果:428例患儿中,共有98例发生不良反应,发生率为22.9%,其中胃肠道不良反应53例(12.4%),注射部位疼痛22例(5.1%),静脉炎12例(2.8%),皮肤瘙痒4例(0.9%),皮疹2例(0.5%),肝功能异常3例(0.7%),血小板减少1例(0.2%),嗜睡1例(0.2%)。按不良反应诊断标准分为肯定24例,很可能23例,可能51例。Logistic回归分析显示,低龄[OR=0.811,95%CI(0.754,0.842),P=0.000]、长疗程[OR=0.1.357,95%CI(1.212,1.519),P=0.000]是发生不良反应的危险因素。结论:低龄、使用疗程较长是导致患儿静脉注射用阿奇霉素后发生不良反应的可能危险因素,儿童用药时应严密观察,控制疗程,以降低不良反应的发生。
ABSTRACT: OBJECTIVE: To analyze the risk factors of adverse reaction in children induced by Azithromycin for injection. METHODS: Data and medication of 428 children used Azithromycin for injection were retrospectively collected, and logistic regression method was used to analyze the risk factors of adverse reactions that likely to occur. RESULTS: In the 428 children, 98 reported adverse reactions with incidence of 22.9%, among which, 53 showed gastrointestinal adverse reactions (12.4%), 22 showed pain in injection site (5.1%), 12 showed phlebitis (2.8%), 4 showed pruritus (0.9%), 2 showed rash (0.5%), 3 showed liver function abnormalities (0.7%), 1 showed thrombocytopenia (0.2%) and 1 showed drowsiness (0.2%). According to adverse reactions diagnostic criteria, 24 were sure, 23 were very likely and 51 were possible. Logistic regression analysis showed younger age [OR=0.811,95% CI(0.754, 0.842),P=0.000] and long duration [OR=0.1.357, 95% CI(1.212,1.519),P=0.000] might the rick factors that caused adverse reactions. CONCLUSIONS: Younger age and long duration are the possible rick factors that caused adverse reactions in children after intravenous administration of azithromycin, close observation and controlling duration should be noticed to reduce the incidence of adverse reactions in children medication.
期刊: 2016年第27卷第24期
作者: 焦伟杰,高天曙,陈团营,侯瑞英,李雪静,伏晓
AUTHORS: JIAO Weijie,GAO Tianshu,CHEN Tuanying,HOU Ruiying,LI Xuejing,FU Xiao
关键字: 阿奇霉素;儿童;不良反应;危险因素
KEYWORDS: Azithromycin; Children; Adverse reaction; Risk factor
阅读数: 596 次
本月下载数: 9 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!