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盐酸纳洛酮联合丹参注射液治疗新生儿缺氧缺血性脑病的临床观察
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| 篇名： | 盐酸纳洛酮联合丹参注射液治疗新生儿缺氧缺血性脑病的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察盐酸纳洛酮联合丹参注射液治疗新生儿缺氧缺血性脑病（HIE）的临床疗效及安全性。方法：104例HIE患儿按照随机数字表法分为观察组和对照组，各52例。对照组患儿给予盐酸纳洛酮注射液0.02 mg/kg，ivgtt，qd，以及常规对症治疗；观察组患儿在对照组基础上给予丹参注射液4～6 ml加入10％葡萄糖注射液20 ml中，ivgtt，qd。两组患儿疗程均为7 d。比较两组患儿临床疗效、症状和体征恢复情况，血清基质金属蛋白酶（MMP）9、白细胞介素（IL）6、肿瘤坏死因子（TNF）α水平，脑血流动力学参数以及不良反应发生情况。结果：两组患儿治疗前的血清MMP-9、IL-6、TNF-α及脑血流动力学参数比较，差异均无统计学意义（P＞0.05）。观察组患儿总有效率（92.31％）明显高于对照组（75.00％），治疗后意识障碍恢复时间、原始反射恢复时间和肌张力恢复时间均明显短于对照组，血清MMP-9、IL-6和TNF-α水平均明显低于对照组，收缩期峰值流速（PSFV）、舒张末期流速（EDFV）明显高于对照组，差异均有统计学意义（P＜0.05）；观察组患儿治疗后阻力指数（RI）低于对照组，但差异无统计学意义（P＞0.05）。两组患儿均未见明显不良反应发生。结论：盐酸纳洛酮联合丹参注射液可明显改善新生儿HIE症状、体征恢复情况，降低血清MMP-9、IL-6、TNF-α水平，改善脑血流动力学参数水平，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of naloxone hydrochloride combined with Danshen injection in the treatment of neonatal hypoxic ischemic encephalopathy （HIE）. METHODS： 104 patients with HIE were randomly divided into observation group and control group with 52 cases in each group. The control group was treated with Naloxone hydrochloride injection 0.02 mg/kg，ivgtt，qd and conventional symptomatic treatment； while observation group was additionally treated with Danshen injection 4-6 ml+10％ Glucose injection 20 ml， ivgtt， qd， on the basis of the control group. Treatment course of 2 groups lasted for 7 d. Clinical efficacy， symptom and sign recovery of 2 groups were compared， as well as levels of serum MMP-9， IL-6 and TNF-α， cerebral hemodynamic parameters and ADR. RESULTS： There was no statistical significance in MMP-9，IL-6，TNF-α and cerebral hemodynamic parameters before treatment （P＞0.05）. The total effective rate of observation group （92.31％） was significantly higher than that of control group （75.00％）； after treatment， the recovery time of consciousness disturbance， primitive reflex and muscle tension in the observation group were shorter than those in the control group； the levels of serum MMP-9， IL-6 and TNF-α in observation group were significantly lower than those in control group； peak systolic flow velocity （PSFV）， end-diastolic flow velocity （EDTV） were higher in the observation group than in the control group， with statistical significance （P＜0.05）； resistance index （RI） was lower than in control group， but without statistical significance （P＞0.05）. No ADR was observed in 2 groups. CONCLUSIONS： Naloxone hydrochloride combined with Danshen injection can significantly promote HIE and signs recovery， reduce the levels of serum MMP-9， IL-6 and TNF-α， and improve hemodynamic parameters with good safety. |
| 期刊： | 2016年第27卷第23期 |
| 作者： | 娄元俊，史华，单海军，曹彩虹 |
| AUTHORS： | LOU Yuanjun，SHI Hua，SHAN Haijun，CAO Caihong |
| 关键字： | 丹参注射液；盐酸纳洛酮注射液；新生儿缺氧缺血性脑病；疗效；基质金属蛋白酶9；白细胞介素6；肿瘤坏死因子α；脑血流动力学参数 |
| KEYWORDS： | Danshen injection； Naloxone hydrochloride injection； Neonatal hypoxic ischemic encephalopathy； Therapeutic efficacy； MMP-9， IL-6； TNF-α； Cerebral hemodynamic parameters |
| 阅读数： | 222 次 |
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