我院2012-2015年抗菌药物使用与细菌耐药率的相关性分析
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篇名: 我院2012-2015年抗菌药物使用与细菌耐药率的相关性分析
TITLE:
摘要: 目的:为临床合理应用抗菌药物提供参考。方法:统计我院2012年1月-2015年12月抗菌药物的使用情况,计算其用药频度(DDDs),统计同期细菌耐药率,采用Pearson相关性分析法考察两者的相关性。结果:2012-2015年,我院患者应用抗菌药物DDDs排名前3位的依次为头孢菌素类、大环内酯类和喹诺酮类;检出率排名前5位的菌株包括大肠埃希菌、铜绿假单孢菌、肺炎克雷伯菌、鲍曼不动杆菌和金黄色葡萄球菌。亚胺培南西司他丁钠的DDDs分别与铜绿假单孢菌耐药率及革兰氏阴性菌总耐药率呈正相关(r分别为0.95、0.98,P<0.05),美罗培南的DDDs与肺炎克雷伯菌的耐药率呈正相关(r=0.97,P<0.05),哌拉西林钠舒巴坦钠的DDDs与铜绿假单胞菌的耐药率呈负相关(r=-0.98,P<0.05)。结论:抗菌药物的DDDs与细菌耐药率具有一定的相关性,应有计划地、科学地选用抗菌药物,以减少细菌耐药的发生。
ABSTRACT: OBJECTIVE: To provide reference for clinical rational use of antibiotics. METHODS: The use of antibiotics in our hospital from Jan. 2012 to Dec. 2015 was analyzed, the DDDs was calculated, bacterial resistance rates over the same period was analyzed, and the relationship between them were analyzed with Pearson method. RESULTS: During 2012-2015, the top 3 antibiotic DDDs in our hospital were cephalosporins, macrolides and quinolones; bacterial with the top 5 detection rate was Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter Bauman and Staphylococcus aureus; the DDDs of imipenem cilastatin sodium showed a positive correlation with the resistance rate of P. aeruginosa (r=0.95,P<0.05) and the total resistance rate of Gram-negative bacteria (r=0.98, P<0.05), meropenem showed a positive correlation with the resistance rate of K. pneumoniae (r=0.97,P<0.05), piperacillin sulbactam sodium showed a negative correlation with the resistance of P. aeruginosa (r=-0.98,P<0.05). CONCLUSIONS: DDDs is correlated with the antibiotic drug resistance rate of bacteria, which should be planned and scientific used to reduce the bacterial resistance.
期刊: 2016年第27卷第23期
作者: 韩凤昭,李振知
AUTHORS: HAN Fengzhao,LI Zhenzhi
关键字: 抗菌药物;耐药率;用药频度;相关性
KEYWORDS: Antibacterial drug; Drug resistance; DDDs; Correlation
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