阿司匹林抵抗的基因多态性及个体化治疗
x

请在关注微信后,向客服人员索取文件

篇名: 阿司匹林抵抗的基因多态性及个体化治疗
TITLE:
摘要: 目的:为阿司匹林用于心血管疾病的个体化治疗提供理论依据。方法:收集近年来国内外相关研究文献,进行归纳和总结。结果与结论:患者的基因多态性可显著影响血小板活性。GPⅢa PLA2、PEAR1和PTGS1等基因突变与阿司匹林抵抗有一定的相关性,不同的基因突变发生阿司匹林抵抗的比例和心血管事件发生率有显著性差异。根据临床基因型检测结果并结合其他因素合理调整给药方案实行个体化治疗,可以降低患者阿司匹林抵抗和心血管不良事件的发生率。
ABSTRACT: OBJECTIVE: To provide theoretical foundation for individualized treatment of aspirin in patients with cardiovascular disease. METHODS: Domestic and foreign literatures in recent years were collected and summarized. RESULTS & CONCLUSIONS: The gene polymorphism can significantly affect the platelet activity. GPIII a PLA2, PEAR1 and PTGS1 alleles are associated with aspirin resistance, and cardiovascular events have significant difference in different genotype patients. Adjusting reasonably dosage regimen and conducting individualized treatment according to the genetic testing result and other factors can reduce aspirin resistance and the incidence of cardiovascular adverse events in the patients.
期刊: 2016年第27卷第23期
作者: 彭文星,冯频频,石秀锦,仇琪,杜海燕,林阳
AUTHORS: PENG Wenxing,FENG Pinpin,SHI Xiujin,QIU Qi,DU Haiyan,LIN Yang
关键字: 阿司匹林抵抗;基因多态性;个体化治疗
KEYWORDS: Aspirin resistance; Gene polymorphism; Individualized treatment
阅读数: 435 次
本月下载数: 27 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!