0.03%他克莫司软膏的体外透皮吸收研究
x

请在关注微信后,向客服人员索取文件

篇名: 0.03%他克莫司软膏的体外透皮吸收研究
TITLE:
摘要: 目的:研究0.03%他克莫司软膏经离体裸鼠皮的透皮吸收情况,并比较国产受试制剂与进口参比制剂的差异。方法:采用改良Franz扩散池法进行体外透皮试验,以高效液相色谱-质谱法(HPLC-MS)测定国产受试制剂和进口参比制剂0.03%他克莫司软膏的体外透皮渗透量、渗透速率和滞后时间。结果:受试制剂与参比制剂的24 h体外透皮累积渗透量分别为(3 907±1 191)、(3 896±1 064) ng/cm2,渗透速率分别为186.7、182.9 ng/(cm2·h),滞后时间分别为1.95、2.00 h,二者差异无统计学意义(P>0.05)。结论:受试制剂有良好的透皮性能,其在裸鼠离体皮肤的透皮吸收性能与参比制剂相当。
ABSTRACT: OBJECTIVE: To study the percutaneous absorption of 0.03% Tacrolimus ointment, and to compare the difference of domestic test preparation and imported reference preparation. METHODS: Modified Franz diffusion cells were adopted in transdermal test in vitro; HPLC-MS method was used to determine permeation amount and rate in vitro, delay time of domestic test preparation and imported reference preparation 0.03% Tacrolimus ointment. RESULTS: 24 h in vitro permeation amount of test and reference preparations were (3 907±1 191) and (3 896±1 064) ng/cm2; permeation rates were 186.7 and 182.9 ng/(cm2·h); delay time were 1.95 and 2.00 h, respectively(P>0.05). CONCLUSIONS: Test preparation shows good percutaneous property, and is similar to reference preparation in penetration absorbency through nude mice skin.
期刊: 2016年第27卷第22期
作者: 张鹏威,苏文琴,邝少轶,刘玮
AUTHORS: ZHANG Pengwei,SU Wenqin,KUANG Shaoyi,LIU Wei
关键字: 他克莫司软膏;体外透皮吸收;裸鼠;高效液体色谱-质谱法
KEYWORDS: Tacrolimus ointment; Percutaneous absorption in vitro; Nude mice; HPLC-MS
阅读数: 213 次
本月下载数: 6 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!