不同剂量盐酸氨溴索对开胸手术围术期患者肺保护作用的影响
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篇名: 不同剂量盐酸氨溴索对开胸手术围术期患者肺保护作用的影响
TITLE:
摘要: 目的:探讨不同剂量盐酸氨溴索对开胸手术围术期患者肺保护作用的影响。方法:60例拟行开胸手术患者随机分为对照组(30例)和观察组(30例)。对照组患者于术前1周至术后1周给予盐酸氨溴索注射液30 mg ,加入0.9%氯化钠注射液100 ml中,静脉滴注,每日2次。观察组患者术前1周至术后1周给予盐酸氨溴索注射液300 mg,加入0.9%氯化钠注射液100 ml中,静脉滴注,每日2次。所有患者术后均给予第二代头孢菌素类抗菌药物抗感染。观察两组患者术前1周、术后1周的肺表面活性物质相关蛋白A (SP-A)、细胞间黏附因子(ICAM-1)水平及术后并发症发生情况。结果:术前1周,两组患者SP-A、ICAM-1水平比较,差异均无统计学意义(P>0.05)。术后1周,对照组患者SP-A、ICAM-1水平及观察组患者ICAM-1水平均显著高于同组术前1周,但观察组SP-A、ICAM-1低于对照组,差异均有统计学意义(P<0.05);观察组患者SP-A术前1周、术后1周比较,差异均无统计学意义(P>0.05)。观察组患者术后并发症发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:大剂量盐酸氨溴索对开胸手术围术期患者肺保护作用显著优于小剂量盐酸氨溴索,可减少肺部并发症的发生。
ABSTRACT: OBJECTIVE: To investigate the effect of different doses ambroxol hydrochloride on lung protection of patients in perioperative thoracotomy. METHODS: 60 patients in perioperative thoracotomy were randomly divided into control group(30 cases) and observation group(30 cases). Control group received 30 mg Ambroxol hydrochloride injection from 1 week before surgery to 1 week after surgery, adding into 100 ml 0.9% Sodium chloride injection, intravenously, twice a day. Observation group received 300 mg Ambroxol hydrochloride injection from preoperative 1 week to postoperative 1 week, adding into 100 ml 0.9% Sodium chloride injection, intravenously, twice a day. All patients received the second-generation cephalosporin antimicrobial drugs for anti-infection after surgery. lung surfactant-associated protein A (SP-A), intercellular adhesion molecule (ICAM-1) levels preoperative 1 week and postoperative 1 week, and incidence of postoperative complications in 2 groups were observed. RESULTS: Preoperative 1 week, there were no significant differences in the SP-A and ICAM-1 in 2 groups (P>0.05). Postoperative 1 week, SP-A and ICAM-1 in control group and ICAM-1 in observation group were significantly higher than preoperative 1 week, but SP-A and ICAM-1 in observation group were lower than control group, the differences were statistically significant (P<0.05), there were no significant differences in SP-A in preoperative 1 week and postoperative 1 week (P>0.05). The incidence of postoperative complications in observation group was significantly lower than control group, the difference was statistically significant (P<0.05). CONCLUSIONS: The effect of high-doses ambroxol hydrochloride on lung protection of patients in perioperative thoracotomy is significantly superior to small dose, which can reduce the incidence of lung complications.
期刊: 2016年第27卷第18期
作者: 齐凯,熊汉鹏,刘小雄,谢琰,熊国江,吕伟,邓海龙
AUTHORS: QI Kai,XIONG Hanpeng,LIU Xiaoxiong,XIE Yan,XIONG Guojiang,LYU Wei,DENG Hailong
关键字: 盐酸氨溴索;开胸手术;围术期;肺保护作用;不同剂量
KEYWORDS: Ambroxol hydrochloride; Thoracotomy; Perioperative; Lung protection; Different dose
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