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黄连温胆汤加减治疗肝郁痰阻型广泛性焦虑的临床观察
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| 篇名： | 黄连温胆汤加减治疗肝郁痰阻型广泛性焦虑的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察黄连温胆汤加减治疗肝郁痰阻型广泛性焦虑的临床疗效与安全性。方法：采用回顾性研究方法，将103例肝郁痰阻型广泛性焦虑患者按治疗方案的不同分为观察组（68例）和对照组（35例）。观察组患者采用黄连温胆汤加减方治疗，每日1剂，水煎360 ml，分3次服用；对照组患者服用氟哌噻吨美利曲辛片，每次1片，qd或bid（早晚服用）。两组疗程均为2个月。比较两组患者治疗前后汉密尔顿焦虑量表（HAMA）评分、临床疗效、药物起效时间与副反应量表（TESS）评分。结果：两组患者治疗后2、4周的HAMA评分均显著低于治疗前，且观察组患者下降幅度显著大于对照组，差异均有统计学意义（P＜0.05）。观察组患者的痊愈率（47.06％）和总有效率（89.71％）均明显高于对照组（分别为20.00％、71.43％），差异均有统计学意义（P＜0.05）；观察组患者治疗第1周的起效率显著低于对照组，但治疗后4、8周的起效率显著高于对照组，差异均有统计学意义（P＜0.05）。治疗后4、8周，观察组患者的TESS评分显著低于对照组，差异有统计学意义（P＜0.05）。结论：黄连温胆汤加减对肝郁痰阻型广泛性焦虑的临床疗效较好，治疗1个月后的改善情况优于化学药且不良反应少。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Jiajian huanglian wendan decoction for liver stagnation and phlegm type generalized anxiety. METHODS： In retrospective study， 103 patients with liver stagnation and phlegm type generalized anxiety were divided into observation group （68 cases） and control group （35 cases）. Observation group received Jiajian huanglian wendan decoction， one dose a day， fried into 360 ml， take 3 times； control group was given Flupentixol and melitracen tablet， one piece each time， qd or bid （take morning and evening）. Treatment course of 2 groups lasted for 2 months. HAMA score before and after treatment， clinical efficacy， drug onset time and TESS were compared between 2 groups. RESULTS： HAMA score of 2 groups 2 and 4 weeks after treatment was significantly lower than before treatment， the observation group was significantly significant than the control group， with statistical significance （P＜0.05）. Cure rate （47.06％） and total effective rate （89.71％） of observation group were significantly higher than those of control group （20.00％， 71.43％）， with statistical significance （P＜0.05）. The onset rate of observation group was significantly lower than that of control group at the first week of treatment， but significantly higher than control group 4 and 8 weeks after treatment， with statistical significance （P＜0.05）. TESS of observation group was significantly lower than that of control group 4 and 8 weeks after treatment， with statistical significance （P＜0.05）. CONCLUSIONS： Jiajian Huanglian wendan decoction shows good clinical efficacy for liver stagnation and phlegm type generalized anxiety and is better than chemical drug in the improvement one month after treatment with less ADR. |
| 期刊： | 2016年第27卷第14期 |
| 作者： | 刘琪，王瑞，赵鸣芳，樊圣丽 |
| AUTHORS： | LIU Qi，WANG Rui，ZHAO Mingfang，FAN Shengli |
| 关键字： | 黄连温胆汤；肝郁痰阻；广泛性焦虑 |
| KEYWORDS： | Huanglian wendan decoction； Liver stagnation and phlegm； Generalized anxiety |
| 阅读数： | 321 次 |
| 本月下载数： | 1 次 |
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