0.9%与3%氯化钠溶液用于雾化治疗喘息性肺炎患儿的临床观察
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篇名: 0.9%与3%氯化钠溶液用于雾化治疗喘息性肺炎患儿的临床观察
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摘要: 目的:比较0.9%与3%氯化钠溶液用于雾化治疗喘息性肺炎患儿的临床疗效及安全性。方法:选取喘息性肺炎患儿150例,按随机数字表法分为A组和B组,各75例。两组患儿均行吸入复方异丙托溴铵溶液+吸入用布地奈德混悬液+硫酸特布他林雾化液雾化治疗方案,A组患儿采用0.9%氯化钠溶液作为雾化溶剂,B组患儿采用3%氯化钠溶液作为雾化溶剂。观察两组患儿临床疗效、临床症状体征消失时间、住院时间及治疗前后临床严重性评分、呼吸频率、血氧饱和度水平,并比较不良反应发生率。结果:B组患儿总有效率显著高于A组(94.12% vs. 83.53%),差异有统计学意义(P<0.05);B组患儿临床症状体征消失时间和住院时间均显著短于A组,差异有统计学意义(P<0.05)。治疗前,两组患儿临床严重性评分、呼吸频率及血氧饱和度水平比较,差异无统计学意义(P>0.05);治疗后,B组患儿临床严重性评分、呼吸频率及血氧饱和度水平显著优于A组,差异有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论:3%氯化钠溶液作为溶剂用于雾化治疗喘息性肺炎患儿疗效优于0.9%氯化钠溶液,且未增加药品不良反应。
ABSTRACT: OBJECTIVE: To compare clinical efficacy and safety of 0.9% and 3% Sodium chloride solution for atomization inhalation therapy in children with asthmatic pneumonia. METHODS: 150 children with asthmatic pneumonia were selected and randomly divided into group A and B with 75 cases in each group. Both group received atomization regimen of Compound ipratropium bromide+budesonide+terbutaline; group A was given 0.9% Sodium chloride solution as solvent, and group B was given 3% Sodium chloride solution as solvent. Clinical efficacy, clinical symptom and sign disappearance time, hospitalization time were observed in 2 groups, and clinical severity score, respiratory rate and oxygen saturation level were also observed before and after treatment; the incidence of ADR was compared. RESULTS: The clinical efficacy of group B was significantly better than that of group A(94.12% vs. 83.53%), with statistical significance (P<0.05). The time of symptom and sign disappearance and hospitalization time of group B were significantly shorter than those of group A, with statistical significance(P<0.05). Before treatment, there was no statistical significance in clinical severity score, respiratory rate and oxygen saturation level between 2 groups (P>0.05). After treatment, clinical severity score, respiratory rate and oxygen saturation level of group B was significantly better than those of group A, with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS: 3% Sodium chloride solution as solvent is suitable for atomization inhalation therapy in children with asthmatic pneumonia and doesn’t increase ADR.
期刊: 2016年第27卷第14期
作者: 梅瑰,苏群燕
AUTHORS: MEI Gui,SU Qunyan
关键字: 0.9%氯化钠溶液;3%氯化钠溶液;雾化吸入;喘息性肺炎;疗效;不良反应
KEYWORDS: 0.9% Sodium chloride solution; 3% Sodium chloride solution; Atomization inhalation; Asthmatic pneumonia; Therapeutic efficacy; ADR
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