复方甘草酸苷致不良反应文献分析
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篇名: 复方甘草酸苷致不良反应文献分析
TITLE:
摘要: 目的:探讨复方甘草酸苷致不良反应(ADR)发生的一般规律及特点。方法:以“复方甘草酸苷”“不良反应”为检索词,检索万方数据知识服务平台和中国知网2010年1月-2015年12月国内医药期刊上公开发表的有关复方甘草酸苷所致ADR个案报道的文献,进行统计、分析。结果:收集文献27篇,获取ADR有效病例34例。其中,男性发生比例高于女性(58.82% vs. 41.18%),好发于50岁以上人群;以注射给药方式最为常见(30例,88.24%);ADR多发生在给药30 min内(13例,38.23%);ADR累及器官/系统以全身性损害居首位(21例次,24.71%),临床表现以过敏性休克为多。34例患者经停药对症治疗,预后良好,无死亡病例报告。结论:复方甘草酸苷临床应用广泛,使用过程中应严格把握适应证,加强用药监测,尤其是50岁以上患者,注意患者用药前教育,以减少ADR的发生。
ABSTRACT: OBJECTIVE: To discuss the general rule and characteristics of Compound glycyrrhizin-induced ADR. METHODS: Retrieved from Wanfang database and CNKI, Compound glycyrrhizin-induced ADR reports published on domestic medical journals were analyzed statistically during Jan. 2010 to Dec. 2015. RESULTS: 27 literatures were collected, involving 34 ADR cases. The propertion of male was more than that of female (58.82% vs. 41.18%); ADR often occurred in patients aged more than 50 years;main route of administration was injection (30 cases, 88.24%); ADR mainly occurred with 30 min after medication (13 cases, 38.23%); main ADR were organ/system and systemic damage (21 times, 24.70%), and allergic shock was the most common clinical manifestation. 34 cases received symptomatic treatment after drug withdrawal and obtain good prognosis. There was no death case. CONCLUSIONS: Compound glycyrrhizin is commonly applied in clinic, which should strictly abide by the indications. Great importance should be attached to medication monitoring, especially in patients aged more than 50 years and pre-medication education to reduce the occurrence of ADR.
期刊: 2016年第27卷第14期
作者: 高贵元,陈丽华,张芳,喻剑,史娜,陈树和
AUTHORS: GAO Guiyuan,CHEN Lihua,ZHANG Fang,YU Jian,SHI Na,CHEN Shuhe
关键字: 个案报道;复方甘草酸苷;不良反应;文献分析
KEYWORDS: Case reports; Compound glycyrrhizin; ADR; Literature analysis
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