国产与进口亚胺培南西司他丁钠治疗重症下呼吸道感染的成本-效果比较
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篇名: 国产与进口亚胺培南西司他丁钠治疗重症下呼吸道感染的成本-效果比较
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摘要: 目的:分析国产与进口亚胺培南西司他丁钠治疗重症下呼吸道感染的成本-效果,并进行比较。方法:采用回顾性研究方法。选取57例使用亚胺培南西司他丁钠治疗重症下呼吸道感染的患者,分为国产组(30例)和进口组(27例)。比较两组患者的临床疗效和不良反应发生情况,并应用药物经济学原理对两种治疗方案进行成本-效果分析。本研究中的成本只考虑每组每位患者1个疗程的药品费。结果:国产组与进口组治疗重症下呼吸道感染的成本分别为1 833.90元和2 373.90元;有效率分别为80.00%和92.59%,差异有统计学意义(P<0.05);不良反应发生率分别为26.67%和18.52%,差异无统计学意义(P>0.05)。国产组与进口组的成本-效果比分别为22.92和25.64,增量成本-效果比为42.89;敏感度分析国产组与进口组的成本-效果比分别为20.63和23.07,增量成本-效果比为38.60,与成本-效果分析结果一致。结论:国产亚胺培南西司他丁钠治疗重症下呼吸道感染略显经济学优势,但进口亚胺培南西司他丁钠的疗效显著优于国产组,临床应根据患者具体情况选择。
ABSTRACT: OBJECTIVE: To analyze and compare the cost-effectiveness of domestic and imported imipenem and cilastatin sodium for severe lower respiratory tract infection. METHODS: In retrospective study, 57 cases of severe lower respiratory tract infection receiving imipenem and cilastatin sodium were selected and divided into domestic group (30 cases) and imported group (27 cases). Clinical efficacy and ADR were compared between 2 groups, and pharmacoeconomic principle was used to analyze the cost-effectiveness of 2 therapy plans. In the study, the cost only included drug cost of apatient in each group for a treatment course. RESULTS: The cost of domestic group and imported group were 1 833.90 yuan and 2 373.90 yuan, and the effective rates were 80.00% and 92.59%, with statistical significance (P<0.05); the incidence of ADR were 26.67% and 18.52% there was no statistical significance between 2 groups (P>0.05). The cost-effectiveness ratio (C/E) of 2 groups were 22.92 and 25.64,and the incremental cost-effectiveness ratio(ΔC/ΔE) was 42.89. Those of sensitivity test were 20.63 and 23.07, ΔC/ΔE was 38.60, which was consistent with the result of cost-effectiveness analysis. CONCLUSIONS: In the treatment of severe lower respiratory tract infection, domestic imipenem and cilastatin sodium shows economic advantage. Imported imipenem cilastatin sodium is better than domestic one in therapeutic efficacy. Drug should be selected according to the condition of patients.
期刊: 2016年第27卷第14期
作者: 李梅,李琼阁,高靓,戚宝和,盛伟华
AUTHORS: LI Mei,LI Qiongge,GAO Liang,QI Baohe,SHENG Weihua
关键字: 亚胺培南西司他丁钠;下呼吸道感染;成本-效果分析;国产;进口
KEYWORDS: Imipenem and cilastatin sodium; Lower respiratory tract infection; Cost-effectiveness analysis; Domestic; Imported
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