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异维A酸红霉素凝胶治疗轻中度寻常痤疮的疗效观察
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| 篇名： | 异维A酸红霉素凝胶治疗轻中度寻常痤疮的疗效观察 |
| TITLE： | |
| 摘要： | 目的：观察异维A酸红霉素凝胶治疗轻中度寻常痤疮的疗效和安全性。方法：120例轻中度寻常痤疮患者随机均分为观察组和对照组。观察组患者于每晚临睡前给予异维A酸红霉素凝胶适量，涂抹于患处，每日1次；对照组患者于每晚临睡前给予维胺酯维E乳膏适量，涂抹于患处，每日1次 。两组患者治疗前均彻底清洁患处皮肤后使用药品，治疗期间不使用化妆品，饮食清淡忌辛辣，作息规律少熬夜。两组疗程均为2个月。观察两组患者的临床疗效，治疗前后各皮损积分、皮脂分泌率（SER）及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者各皮损积分、SER均显著低于同组治疗前，而观察组皮损数量积分、皮疹形态积分、SER均低于对照组，差异均有统计学意义（P＜0.05）；但皮疹类型积分两组间比较，差异无统计学意义（P＞0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：异维A酸红霉素凝胶治疗轻中度寻常痤疮疗效显著，且安全性较好。 |
| ABSTRACT： | OBJECTIVE：To observe the efficacy and safety of Isotretinoin erythromycin gel in the treatment of mild-to-moderate acne vulgaris. METHODS： 120 patients with mild-to-moderate acne vulgaris were randomly divided into observation group and control group. Observation group was given appropriate amount of Isotretinoin erythromycin gel in affected areas every night before bed， once a day； control group was given appropriate amount of Viaminate vitamin E cream in affected areas every night before bed， once a day. The skin was thoroughly cleaned before treatment， no cosmetics and no spicy diet， rest rules and less staying up late. The treatment course for both groups was 2 months. Clinical efficacy， skin lesion scores， inflammation sebum secretion rate （SER） before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant（P＜0.05）. after treatment， the skin lesion scores and SER in 2 groups were significantly lower than before， the number of skin lesions， rash forms and SER in observation group were significantly lower than control group， the differences were statistically significant （P＜0.05）； but there was no significant difference in the rash types between 2 groups （P＞0.05）. And there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS： Isotretinoin erythromycin gel has significant efficacy in the treatment of mild-to-moderate acne vulgaris， with good safety. |
| 期刊： | 2016年第27卷第9期 |
| 作者： | 牛金茹，阮晓兰 |
| AUTHORS： | NIU Jinru，RUAN Xiaolan |
| 关键字： | 异维A酸红霉素凝胶；轻中度寻常痤疮；疗效；安全性 |
| KEYWORDS： | Isotretinoin erythromycin gel； Mild-to-moderate acne vulgaris； Efficacy； Safety |
| 阅读数： | 322 次 |
| 本月下载数： | 2 次 |
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