健胃愈疡片联合雷贝拉唑治疗肝胃不和型消化性溃疡的临床观察
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篇名: 健胃愈疡片联合雷贝拉唑治疗肝胃不和型消化性溃疡的临床观察
TITLE:
摘要: 目的:观察健胃愈疡片联合雷贝拉唑治疗肝胃不和型消化性溃疡的疗效和安全性。方法:116例肝胃不和型消化性溃疡患者随机均分为观察组和对照组。两组患者均给予流质或半流质饮食,严禁食用辛辣等刺激性食物,并给予维生素等常规治疗;在此基础上,对照组患者给予雷贝拉唑钠肠溶片20 mg,于早晨用温开水整片吞服,严禁咀嚼或压碎后服用,每日1次;观察组患者在对照组治疗的基础上加用健胃愈疡片1.2 g,用温开水送服,每日4次。两组均以6周为1个疗程,连续治疗2个疗程。观察两组患者的临床疗效,治疗前后幽门螺杆菌(Hp)情况,炎症因子[肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、C反应蛋白(CRP)]水平及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者Hp情况、炎症因子水平比较,差异均无统计学意义(P>0.05)。治疗后,两组患者Hp阳性例数及阳性率、炎症因子水平均显著低于同组治疗前,且观察组低于对照组;Hp阴性例数及阴性率均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上, 健胃愈疡片联合雷贝拉唑治疗肝胃不和型消化性溃疡的疗效显著优于单用雷贝拉唑,且安全性相当。
ABSTRACT: OBJECTIVE:To observe the efficacy and safety of Jianwei yuyang tablet combined with rabeprazole in the treatment of liver and stomach disharmony type of peptic ulcer. METHODS: 116 patients with liver and stomach disharmony type of peptic ulcer were randomly divided into observation group and control group. All patients were given liquid or semi-liquid diet, vitamin and other conventional treatment, and spicy food was prohibited; based on it, control group was treated with 20 mg Rabeprazole sodium enteric-coated tablet with warm water to swallow whole in the morning, once a day, chewed or crushed taking were prohibited. Observation group was additionally treated with 1.2 g Jianwei yuyang tablet with warm water, 4 times a day. One course included 6 weeks, and it lasted 2 courses. Clinical efficacy, helicobacter pylori (Hp) eradication, the inflammatory cytokines levels [tumor necrosis factor (TNF)-α, interleukin (IL)-6, C-reactive protein (CRP)] before and after treatment and incidence of adverse reactions in 2 groups were observed. RESULTS: The total effective rate in observation group was significantly higher than control group, the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the Hp eradication and the inflammatory cytokines levels between 2 groups(P>0.05); after treatment, Hp positive cases and positive rates and the inflammatory cytokines levels in 2 groups were significantly lower than before, and observation group was lower than control group, Hp negative cases and negative rates were significantly higher than before, and observation group was higher than control group, the differences were statistically significant(P<0.05). And there was no significant difference in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS: Based on conventional treatment, the efficacy of Jianwei yuyang tablet combined with rabeprazole is superior to rabeprazole alone in the treatment of liver and stomach disharmony type of peptic ulcer, with similar safety.
期刊: 2016年第27卷第9期
作者: 李敏,王艳萍,李震
AUTHORS: LI Min,WANG Yanping,LI Zhen
关键字: 肝胃不和型消化性溃疡;健胃愈疡片;雷贝拉唑;疗效;安全性
KEYWORDS: Liver and stomach disharmony type of peptic ulcer; Jianweiy uyang tablet; Rabeprazole; Efficacy; Safety
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