2005-2014年我国基本药物不良反应文献计量学分析
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篇名: 2005-2014年我国基本药物不良反应文献计量学分析
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摘要: 目的:了解我国基本药物不良反应文献的研究趋势及热点,为促进基本药物合理使用提供参考。方法:计算机检索2005-2014年中国知网数据库、万方数据库、维普数据库收录的基本药物不良反应相关文献,先运用书目信息共现分析系统(BICOMB)2.0版提取关键词、年份及相应文献量、期刊、作者及机构等参量进行文献计量学分析,并构建高频关键词词篇矩阵;然后将该词篇矩阵导入SPSS 21.0进行系统聚类分析;最后使用图形聚类工具包(gCLUTO)1.0版进行关键词词篇共现分析和聚类可视化分析。结果:共检索到文献232篇,刊登在100种期刊上,文献量呈逐年上升转稳态发展趋势;发文量最高的前4位作者分别为李幼平(13篇)和李鸿浩、王莉、杨晓妍(各10篇),发文量最多的前3个机构分别为广州中医药大学第二附属医院/广东省中医院(18篇)、国家食品药品监督管理总局药品评价中心(16篇)、四川大学华西医院中国循证医学中心(13篇)。高频关键词除了“药品不良反应”“基本药物”“基本药物目录”“基本药物制度”“分析”外,还有“合理用药”“中药注射剂”“药品说明书”“抗菌药物”“循证评价与遴选”“乡镇卫生院”;经关键词聚类分析可分为5类。结论:我国基本药物不良反应文献量趋于稳定,内容逐步深入,相关研究结论对促进基本药物合理、安全、有效的使用产生了积极影响,但文献多是从理论和宏观政策上进行论述,且来自药品生产企业的文献较少,儿童基本药物不良反应研究也较少。因此,该领域的研究仍需从定性转向定量,从简单的数据分析转向深入的机制研究,从宏观的政策建议转向微观的具体药物,以更好地促进基本药物合理使用,保障人民群众用药安全。
ABSTRACT: OBJECTIVE:To understand the research trends and hot issues of adverse reaction literature about essential medicines in China, and provide reference for promoting rational use of essential medicines. METHODS: Adverse reaction literature of essential medicines in CNKI, Wanfang Database and VIP Database from 2005 to 2014 were retrieved, Bibliographic information system (BICOMB 2.0) was used to extract keywords, the corresponding literature quantity, journals, authors and institutions for Literature Metrology, article matrix about high-frequency keywords was established; then, import the article matrix into SPSS 21.0 was used for cluster analysis; and finally, graphical cluster toolkit (gCLUTO 1.0) was applied for co-occurrence analysis and vi-sualized cluster analysis. RESULTS: There were 232 word-paper obtained from 100 journals, showing an increasing trend and then turning steady; the top 4 authors respectively were LI Youping (13 articles), LI Honghao, WANG Li, YANG Xiaoyan (each 10 articles), the top 3 institutions respectively were the Second Affiliated Hospital of Guangzhou University of Chinese Medicine / Chinese Medicine Hospital of Guangdong Province (18 articles), Center for Drug Revelation, CFDA (16 articles) and the Chinese Cochrane Center of Sichuan University (13 articles). In addition to “adverse reactions”“essential medicines”“essential medicines system”“analysis”, the high-frequency keyword also included “rational drug use”“TCM injections”“drug instructions”“antibacterial drugs”“evidence-based evaluation and selection”“township hospitals”; 5 clusters were gotten by keywords double cluster analysis. CONCLUSIONS: The literature quantity of adverse reactions about essential medicines in China has gradually stable and the content has gradually thorough, the research conclusion shows a positive effects on promoting the reasonable, safe and effective use of essential medicines, while, the literature is discussed more in theory and macroeconomic policy, and there are less literature from pharmaceutical manufacturers, adverse reactions of essential medicines for children are also less. Therefore, the research areas need to shift from qualitative to quantitative, from simple data analysis to deep mechanism research and from macro-micro policy recommendations to micro specific drugs in order to promote the rational use of essential medicines and make sure the medication safety.
期刊: 2016年第27卷第9期
作者: 赵瑞霞,王慧玲,赵丽玲,张彩云,章锦丽,刘伟
AUTHORS: ZHAO Ruixia,WANG Huiling,ZHAO Liling,ZHANG Caiyun,ZHANG Jinli,LIU Wei
关键字: 基本药物;不良反应;文献计量学;聚类分析
KEYWORDS: Essential medicines; Adverse reactions; Bibliometrics; Cluster analysis
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