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LC-MS/MS法和MEIA法测定人血浆中地高辛浓度的差异比较
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| 篇名： | LC-MS/MS法和MEIA法测定人血浆中地高辛浓度的差异比较 |
| TITLE： | |
| 摘要： | 目的：比较液相色谱-串联质谱（LC-MS/MS）法与微粒子酶联免疫（MEIA）法测定人血浆中地高辛浓度的差异。方法：分别采用LC-MS/MS法与MEIA法对质控样品及50例患者血浆样品中的地高辛浓度进行检测，采用配对t检验比较分析两种方法的检测结果。结果：质控样品检测结果显示，两种方法检测结果间的差异无统计学意义（P＞0.05）；50例患者血浆样品检测结果显示，MEIA法检测结果明显高于LC-MS/MS法，两者差异有统计学意义（P＜0.01）。结论：MEIA法检测结果与临床实际情况相比存在一定的差异，LC-MS/MS法更适于临床地高辛血药浓度的检测。 |
| ABSTRACT： | OBJECTIVE： To compare the methods of LC-MS/MS and MEIA for the determination of digoxin concentrations in human plasma. METHODS： The concentration of digoxin in standard controls and samples from 50 patients were respectively determined by LC-MS/MS and MEIA methods， and the results obtained by the two methods were analyzed using paired t test. RESULTS： There was no statistical difference between the data of standard controls by LC-MS/MS and MEIA methods （P＞0.05）. However， the results of 50 samples from patients showed that MEIA data were significantly higher than LC-MS/MS data， there was statistically significant difference （P＜0.01）. CONCLUSIONS： There is considerable variation between MEIA data and practical data. Compared with the MEIA， LC-MS/MS is more suitable for clinical determination of digoxin plasma concentration. |
| 期刊： | 2016年第27卷第5期 |
| 作者： | 白万军，宋浩静，孙晓利，安静，赫立恩，邱志宏，马杰，郭彩会，董占军 |
| AUTHORS： | BAI Wanjun，SONG Haojing，SUN Xiaoli，AN Jing，HE Lien，QIU Zhihong，MA Jie，GUO Caihui，DONG Zhanjun |
| 关键字： | 地高辛；微粒子酶联免疫法；液相色谱-串联质谱法；血药浓度 |
| KEYWORDS： | Digoxin； MEIA； LC-MS/MS； Plasma concentration |
| 阅读数： | 638 次 |
| 本月下载数： | 13 次 |
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