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玻璃酸钠联合0.1％氟米龙治疗干眼症的临床观察
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| 篇名： | 玻璃酸钠联合0.1％氟米龙治疗干眼症的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察玻璃酸钠滴眼液联合0.1％氟米龙滴眼液治疗中重度干眼症的疗效及安全性。方法：选择确诊的中重度干眼症患者96例（198眼），按随机数字表法分为观察组和对照组，各48例（96眼）。对照组采用玻璃酸钠滴眼液0.04 ml，tid；观察组患者在对照组基础上加用0.1％氟米龙滴眼液0.04 ml，tid，两组均治疗4周。观察两组患者治疗前后眼部症状评分、角膜荧光染色试验、泪膜破裂时间、泪液分泌情况试验、临床疗效及不良反应。结果：治疗后2、4周观察组患者眼部症状评分、角膜荧光素染色、泪膜破裂时间较治疗前显著改善，且显著优于对照组，差异有统计学意义（P＜0.05）；两组患者治疗前后泪液分泌试验结果比较，差异无统计学意义（P＞0.05）；治疗后，观察组患者总有效率（97.92％）显著高于对照组（86.46％），差异有统计学意义（P＜0.05）；两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：玻璃酸钠滴眼液联合0.1％氟米龙滴眼液能提高中重度干眼症患者的临床疗效，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of Sodium hyaluronate eye drops combined with 0.1％ Fluorometholone eye drops in the treatment of moderate and severe dry eye syndrome. METHODS： 96 patients （198 eyes） diagnosed as moderate and severe dry eye syndrome were randomly divided into observation group and control group with 48 cases in each group （96 eyes）. Control group received Sodium hyaluronate eye drops 0.04 ml， tid； observation group was additionally given 0.1％ Fluorometholone eye drops 0.04 ml， tid， on the basis of control group. Both groups received 4 weeks of treatment. Eye symptom score， cornea fluorescent staining， tear film breakup time， lacrimal secretion， clinical efficacy and ADR were observed in 2 groups before and after treatment. RESULTS： After 2 and 4 weeks of treatment， eye symptom score， cornea fluorescent staining and tear film breakup time of observation group were improved significantly， and better than control group， with statistical significance （P＜0.05）. There was no statistical significance in lacrimal secretion between 2 groups before and after treatment （P＞0.05）. After treatment， total effective rate of observation group （97.92％） was significantly higher than that of control group （86.46％）， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Sodium hyaluronate eye drops combined with 0.1％ Fluorometholone eye drops can improve therapeutic efficacy of moderate and severe dry eye syndrome， with good therapeutic efficacy. |
| 期刊： | 2016年第27卷第2期 |
| 作者： | 王咏丽，佟欣，张晓莉，袁建军，万凤伟，吴燕 |
| AUTHORS： | WANG Yongli，TONG Xin，ZHANG Xiaoli，YUAN Jianjun，WAN Fengwei，WU Yan |
| 关键字： | 玻璃酸钠；氟米龙；干眼症；疗效 |
| KEYWORDS： | Sodium hyaluronate； Fluorometholone； Dry eye syndrome； Efficacy |
| 阅读数： | 553 次 |
| 本月下载数： | 8 次 |
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