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脉安宁合剂联合盐酸普罗帕酮片治疗特发性期前收缩患者的临床观察
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| 篇名： | 脉安宁合剂联合盐酸普罗帕酮片治疗特发性期前收缩患者的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察脉安宁合剂与盐酸普罗帕酮片治疗特发性期前收缩（IPC）患者的疗效及安全性。方法：88例IPC患者，按随机数字表法分为对照组A（30例）、对照组B（30例）和治疗组（28例）；对照组A患者给予脉安宁合剂100 ml，bid；对照组B患者给予盐酸普罗帕酮片150 mg，tid；治疗组患者给予同等剂量脉安宁合剂联合盐酸普罗帕酮片治疗，3组患者均治疗4周，观察3组患者治疗后期前收缩疗效、心电图疗效、中医症候疗效、Holter期前收缩总数及不良反应情况。结果：治疗组患者总有效率显著高于对照组A与对照组B（90.00％ vs. 83.33％ vs. 82.14％），差异有统计学意义（P＜0.05）；治疗组患者中医证候总有效率优于对照组A与对照组B（90.00％ vs. 83.33％ vs. 75.00％），差异有统计学意义（P＜0.05）；治疗后，3组患者Holter期前收缩总数显著降低，且治疗组显著低于对照组A与对照组B[（1 936.47±1 913.68）次/d vs. （2 411.65±4 140.29）次/d vs.（2 834.40±4 599.06）次/d]，差异有统计学意义（P＜0.05）；治疗后，3组患者心电图疗效比较，差异无统计学意义（P＞0.05）。3组患者治疗期间均未见明显不良反应发生。结论：脉安宁合剂联合盐酸普罗帕酮片能显著降低患者的期前收缩总数，明显改善中医证候，提高临床疗效，且安全性好。 |
| ABSTRACT： | OBJECTIVE： To observe Mai’anning mixture combined with Propatenonel in the treatment of idiopathic premature contraction （IPC）. METHODS： 88 IPC patients were randomly divided into control group A， control group B and treatment group. Control group A was given Mai’anning mixture 100 ml， bid； control group B was given propatenone 150 ml， tid. Treatment group received equivalent volume of Mai’anning mixture combined with cardiac rhythm therapy. 3 groups received 4 weeks of treatment. Premature contraction eficacy， electro cardiogram eficacy， TCM syndromes eficacy， total number of hdter premature contraltion and ADR were observed in 3 groups after treatment. RESULTS： Total effective rate of treatment groups was significantly higher than control group A and B （90.00％ vs. 83.33％ vs. 82.14％）， with statistical significance （P＜0.05）. Total effective rate of TCM syndrome in treatment group was better than control group A and control group B （90.00％ vs. 83.33％ vs. 75.00％）， with statistical significance （P＜0.05）. After treatment， total Holter premature contraction count of 3 groups decreased significantly， and that of treatment group was lower than that of control group A and control group B [（1 936.47±1 913.68）times/d vs. （2 411.65±4 140.29）times/d vs.（2 834.40±4 599.06）times/d]， with statistical significance （P＜0.05）. After treatment， there was no statistical significance in electrocardiogram among 3 groups （P＞0.05）. No obvious ADR was found in 3 groups during treatment. CONCLUSIONS： Mai’anning mixture combined with Propatenonel can significantly decrease total premature contraction count， improve TCM syndrome and clinical efficacy with good safety. |
| 期刊： | 2016年第27卷第2期 |
| 作者： | 王恒和，程刚，刘兴磊 |
| AUTHORS： | WANG Henghe，CHENG Gang，LIU Xinglei |
| 关键字： | 脉安宁合剂；盐酸普罗帕酮片；特发性期前收缩；疗效；安全性 |
| KEYWORDS： | Maianning mixture； Propatenorel； Idiopathic premature contraction； Efficacy； Safety |
| 阅读数： | 295 次 |
| 本月下载数： | 2 次 |
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