我国18家三级儿童专科医院儿童基本药物可获得性研究
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篇名: 我国18家三级儿童专科医院儿童基本药物可获得性研究
TITLE: CHINA PHARMACY Volume 33,Number 18,September 30,2022 Semimonthly Table of Contents Study on the availability of essential medicines for children at 18 tertiary children ’s hospitals
摘要: 目的 为我国相关决策者制定和完善儿童用药相关政策提供实证依据。方法采用世界卫生组织(WHO)和国际健康行动组织推荐的基本药物标准调查法,基于18家三级儿童专科医院2016年7月-2019年6月的采购数据,调查第7版《WHO儿童基本药物示范目录》(WHOEMLc)中收录药品在样本医院的可获得性及相关影响因素。结果第7版WHOEMLc中的药品在样本医院有采购记录的共有189个活性成分,对应229种药品。吸入用布地奈德混悬液、口服补液盐、注射用免疫球蛋白、注射用水的可获得率为100%。2016年7月-2019年6月的各季度中,均有半数以上的药品可获得率超过50%,各季度中药品可获得率基本保持稳定。心血管系统用药和血液系统用药的整体可获得率最高,而抗寄生虫用药、皮肤科用药的整体可获得率较低。有28种药品(12.2%)未在我国获准用于儿童,属于超说明书用药。已在我国获准可用于儿童和纳入国家基本药物目录的药品的可获得率更高(P<0.05)。结论我国三级儿童专科医院的儿童基本药物可获得性较好,但存在一定的超说明书用药现象。建议我国应尽早出台儿童基本药物目录,推动临床常用品种在儿童人群中的临床试验,并及时更新药品说明书,以保障儿童基本药物的可获得性与安全性。
ABSTRACT: OBJECTIVE To provide emp irical evidence for relevant decision makers in China to formulate and improve policies related to children ’s medicine use . METHODS Based on the purchase data (Jul. 2016-Jun. 2019)of 18 tertiary children ’s hospitals,the availability of medicines included in the 7th edition of WHO Model List of Essential Medicines for Children (WHO EMLc)and their influential factors were investigated according to standard medicine investigation method recommended by the WHO and Health Action International . RESULTS A totally 189 active ingredients listed in the 7th edition of WHO EMLc were available at 18 tertiary children ’s hospitals in China ,which referred to 229 medicines. The availability of Budesonide inhalation suspension,oral rehydration salt ,Immunoglobulin for injection and Water for injection was 100%. In each quarter from Jul . 2016 to Jun . 2019,the availability of more than half of the medicines exceeded 50%,and the availability of the medicines remained basically stable in each quarter . The overall availability of cardiovascular system medicines and blood system medicines was the highest,while that of antiparasitic medicines and dermatology medicines was lower . There were 28 medicines(12.2%)that were not approved for use in children in China ,the use of which were off -label. The medicines which had been approved for children and which were included in national essential medicine list had a significantly higher availability (P<0.05). CONCLUSIONS The availability of essential medicines for children is generally better at tertiary children ’s hospitals in China . But the use of some essential medicines in children are off -label. In order to ensure the safety and the availability of essential medicines for children ,it is suggested to introduce China ’s essential medicines list for children ,to promote clinical trials in children for commonly used medicines,and to updete the drug manual in time .
期刊: 2022年第33卷第18期
作者: 王志远,韩泰森,何摇光,范平安,聂小燕,王晓玲,陈敬,史录文
AUTHORS: WANG Zhiyuan, HAN Taisen,HE Yaoguang,FAN Ping ’an,NIE Xiaoyan,WANG Xiaoling,CHEN Jing,SHI Luwen
关键字: 儿童基本药物;可获得性;三级儿童专科医院;标准调查法
KEYWORDS: essential medicines for children ;availability;
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