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2013－2019年四川省老年患者药品不良反应的回顾性分析
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| 篇名： | 2013－2019年四川省老年患者药品不良反应的回顾性分析 |
| TITLE： | Retrospective Analysis of ADR in Elderly Patients in Sichuan Province during 2013-2019 |
| 摘要： | 目的：了解四川省老年患者（≥65岁）药品不良反应（ADR）报告的现状及特点，为保障其用药安全提供参考。方法：调取2013－2019年四川省ADR监测中心自发呈报系统收集的老年患者ADR报告数据，对报告类型、上报机构、关联性及患者年龄、性别、民族、药物类型、累及器官/系统等情况进行统计分析。结果与结论：7年间，四川省ADR监测中心收集的自发ADR报告共175431例“。一般的”ADR报告的年占比从2013年的78.93％逐年下降至60.50％“；新的一般的”“严重的”ADR报告年占比逐年上升，其中“新的一般的”ADR上升更明显；主要上报机构是医疗机构，年占比为92.79％～98.87％，企业、个人呈报ADR的积极性有待提高；关联性“肯定”的有8031例（4.58％）“，很可能”的有21283（12.13％）“，可能”的有146117例（83.29％）；除272例ADR未报告性别外，其余ADR涉及男性88176例、女性86983例，以65～74岁最多（104962例，59.83％）；报告共涉及19个民族，其中汉族患者166752例（98.72％），彝族、藏族、羌族老年患者ADR涉及药物的类别分布与汉族显著不同（P＜0.01）。上报总频次排名前3位的药物类别为抗感染药（31.10％）、中药（18.27％）、中枢神经系统药物（9.99％）。注射给药途径引发ADR最多（72.12％）；ADR主要累及皮肤及其附件（21.47％）、胃肠系统（19.61％）和中枢及外周神经系统（18.55％）。氨茶碱注射液为唯一连续7年进入引发“新的一般的”ADR排名前10位的药品；连续7年均进入引发“严重的”ADR排名前10位的药品有注射用头孢噻肟钠、注射用头孢曲松钠、注射用头孢哌酮钠舒巴坦钠，临床应予以高度重视。 |
| ABSTRACT： | OBJECTIVE：To investigate the situ ation and characteristics of ADR reports in the elderly patients （≥65 years old ） of Sichuan province ，and to provide reference for guaranteeing the safety of drug use. METHODS ：ADR reporting data of elderly patients collected by spontaneous reporting system of Sichuan ADR monitoring center from 2013 to 2019 were collected ，and then analyzed in respects of report types ，reproting institution ，relationship，patienst’age，gender，nationality，drug type ，organ/system invovled. RESULTS & CONCLUSIONS ：In the past seven years ，175 431 cases spontaneous ADR were collected by Sichuan ADR monitoring center ，and the annual proportion of “general”ADR reports decreased from 78.93％ in 2013 to 60.50％ year by year ； the annual proportion of “new general ”and“serious”ADRs increased year by year ，among which that of “new general ”ADR increased more obviously. The main reporting institutions were medical institutions ，accounting for 92.79％-98.87％ of the total annual reports. The enthusiasm of enterprises and individuals to report ADR needed to be improved ；8 031 cases（4.58％）were “positive”relationship，21 283 cases（12.13％）were“likely”，146 117 cases（83.29％）were“possible”. Except that the gender of 272 cases were not reported ，there were 88 176 male cases and 86 983 female cases ；most of them were 65-74 years old （104 962 cases，59.83％）. The reports covered 19 nationalities，among which the re were 166 752 cases（98.72％）of Han nationality. The distribution of ADR related drug categories in elderly patients of Yi ， Tibetan and Qiang nationalities was significantly different from that of Han nationality （P＜0.01）. The top three drug categories in the total frequency were anti-infective drugs （31.10％），traditional Chinese medicine com （18.27％），and central nervous system drugs （9.99％）. The injection route was the most likely to cause ADR （72.12％）. ADR mainly involved s kin and its appendants （21.47％）， gastrointestinal system （19.61％）and central and peripheral nervous system （18.55％）. Aminophylline injection was the only dr ug in the top 10 drugs leading to “new general ”ADR for consecutive 7 years. Cefotaxime sodium for injection ，Ceftriaxone sodium for injection ，Cefoperazone sodium and sulbactam sodium for injection were the top 10 drugs causing “severe”ADR in consecutive 7 years，which should be paid more attention in clinic. |
| 期刊： | 2020年第31卷第22期 |
| 作者： | 邹林珂，闫峻峰，兰姗，吴承云，刘静，吴行伟，边原，杜姗 |
| AUTHORS： | ZOU Linke，YAN Junfeng ，LAN Shan，WU Chengyun ，LIU Jing，WU Xingwei ，BIAN Yuan，DU Shan |
| 关键字： | 四川省；药品不良反应；老年患者；回顾性分析 |
| KEYWORDS： | Sichuan province ；Adverse drug reactions ；Elderly patients ；Retrospective analysis |
| 阅读数： | 178 次 |
| 本月下载数： | 11 次 |
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