布依药野苏麻的二萜类化学成分研究
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篇名: 布依药野苏麻的二萜类化学成分研究
TITLE: Study on Chemical Constituents of Diterpenoids from Buyi Medicine Isodon coetsa
摘要: 目的:对布依药野苏麻的二萜类成分进行研究,为其资源开发利用提供参考。方法:采用硅胶柱、SehadexLH-20凝胶柱、MCI柱等对野苏麻的95%甲醇提取物进行分离纯化,通过波谱分析(质谱、氢谱、碳谱)技术鉴定所得化合物的结构,并与民间混用苗药“喔嘎良”的活性成分进行比对。结果与结论:从野苏麻中分离鉴定出10个二萜类化合物,分别为细锥香茶菜乙素(化合物Ⅰ)、大锥香茶菜乙素(化合物Ⅱ)、细锥香茶菜甲素(化合物Ⅲ)、EnanderianinN(化合物Ⅳ)、细锥香茶菜丁素(化合物Ⅴ)、大锥香茶菜甲素(化合物Ⅵ)、线纹香茶菜酸(化合物Ⅶ)、RubesanolideD(化合物Ⅷ)、ExcisaninD(化合物Ⅸ)、ExcisaninK(化合物Ⅹ),其中化合物Ⅶ、Ⅸ、Ⅹ均为首次从该植物中分离得到;化合物Ⅶ(线纹香茶菜酸)为布依药野苏麻与苗药“喔嘎良”中共同含有的活性成分。
ABSTRACT: OBJECTIVE:To st udy the chemical constituents of diterpenoids from Buyi medicine Isodon coetsa ,and to provide reference for the development and utilization of the medicinal resources. METHODS :The 95% methanol extract of Buyi medicine I. coetsa were isolated and purified with silica gel column ,Sehadex LH- 20 gel column and MCI column. The structures of the compounds were obtained by spectral analysis (mass spectrum ,hydrogen spectrum and carbon spectrum ),and then compared with active components of Miao medicine “Isodon flavidus ”. RESULTS & CONCLUSIONS :Ten diterpenoids were obtained from I. coetsa,including rabdocoetsin B (Ⅰ),megathgrin B (Ⅱ),rabdocoetsin A (Ⅲ),enanderianin N (Ⅳ),rabdocoetsin D (Ⅴ), megathyrin A (Ⅵ),lophanic acid (Ⅶ),rubesanolide D (Ⅷ),excisanin D (Ⅸ),excisanin K (Ⅹ). The compounds Ⅶ,Ⅸ and Ⅹ were isolated from this specie for the first time. Compound Ⅶ(lophanic acid )is a common active component in the Buyi medicine I. coetsa and Miao medicine “I. flavidus ”.
期刊: 2020年第31卷第20期
作者: 李继新,叶江海,邹娟,潘炉台,张敬杰
AUTHORS: LI Jixin,YE Jianghai ,ZOU Juan,PAN Lutai,ZHANG Jingjie
关键字: 布依药;野苏麻;二萜类;化学成分;鉴定
KEYWORDS: Buyi medicine ;Isodon coetsa ;Diterpenoids;Chemical constituents ;Identification
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