欧前胡素柔性脂质体凝胶的制备及质量评价
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篇名: 欧前胡素柔性脂质体凝胶的制备及质量评价
TITLE: Preparation and Quality Evaluation of Imperatorin Ultradeformable Liposomes Gel
摘要: 目的:制备欧前胡素柔性脂质体凝胶(IMP-UDLs-Gel),并对其进行质量评价。方法:在单因素考察的基础上,以12h累积透过量(Q12h)为评价指标,采用正交试验法对IMP-UDLs-Gel处方中的卡波姆940比例、甘油比例和丙二醇比例进行考察,筛选最优处方,并对最优处方所制备的IMP-UDLs-Gel进行质量评价。结果:IMP-UDLs-Gel最优处方为卡波姆940比例1%、甘油比例15%、丙二醇比例10%。所制得的IMP-UDLs-Gel的Q12h为(11.543±0.241)μg/cm2;外观为乳白色、半透明状;粒径为(93.13±1.68)nm,多分散系数为0.268±0.012,Zeta电位为(-24.96±1.99)mV;pH为7.32±0.03;黏度为(45.37±1.27)g·s;稳态流量为(0.727±0.002)μg·h/cm2,滞后时间为(4.358±0.175)h,表观渗透系数为1.392×10-3cm/h,且具有良好的物理稳定性和光稳定性。结论:建立的制备方法稳定可行,所制备的IMP-UDLs-Gel具有良好的黏附性、稳定性和透皮性。
ABSTRACT: OBJECTIVE:To prepare Imperatorin ultradeformable liposomes gel (IMP-UDLs-Gel),and to evaluate its quality. METHODS:Based on single factor test ,using 12 h accumulative penetration amount (Q12h)as evaluation index ,the proportion of carbomer 940,glycerol and propyl glycol in formulation of IMP-UDLs-Gel were investigated by orthogonal test. The optimal formulation was screened. The quality of IMP-UDLs-Gel prepared with the optimal formulation was evaluated. RESULTS :The optimal formulation of IMP-UDLs-Gel included carbomer 940 proportion of 1%,glycerol proportion of 15% and propyl glycol proportion of 10%. Q12 h of IMP-UDLs-Gel was (11.543±0.241)μg/cm2;the appearance was milky white and translucent ;the particle size was (93.13±1.68)nm,PDI was 0.268±0.012,Zeta potential was (-24.96±1.99)mV;pH was 7.32±0.03; viscosity was (45.37±1.27)g·s;steady flow was (0.727±0.002)μg·h/cm2,lag time was (4.358±0.175)h,apparent permeability coefficient was 1.392×10-3 cm/h,and it has good physical and optical stability. CONCLUSIONS :The preparation method is stable and feasible ,and the prepared IMP-UDLs-Gel has good adhesion ,stability and transdermal property.
期刊: 2020年第31卷第09期
作者: 崔雪惠,陈世洪,邱金娣,班俊峰,杨楠楠,倪庆纯,潘钊言,谢清春,陈燕忠,吕竹芬
AUTHORS: CUI Xuehui,CHEN Shihong,QIU Jindi, BAN Junfeng,YANG Nannan,NI Qingchun,PAN Zhaoyan,XIE Qingchun,CHEN Yanzhong,LYU Zhufen
关键字: 欧前胡素;柔性脂质体;凝胶;处方优化;制备;质量评价;透皮性
KEYWORDS: Imperatorin; Ultradeformable liposomes ; Gel; Formulation optimization ; Preparation; Quality evaluation ;
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