蒲黄不同药用部位的质量比较
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篇名: 蒲黄不同药用部位的质量比较
TITLE: Comparison of Medicinal Part Quality of Typha angustifolia
摘要: 目的:比较草蒲黄和蒲黄花粉的质量差异,为蒲黄质量标准的完善提供科学依据。方法:收集15批次草蒲黄,按照2015年版《中国药典》中蒲黄相关方法筛分出筛下蒲黄花粉和筛上杂质(花丝、花药),通过杂质百分比、性状、显微镜鉴别、薄层色谱鉴别确证草蒲黄和蒲黄花粉、花丝、花药的特征和成分,采用高效液相色谱法测定草蒲黄、蒲黄花粉、筛上杂质(花丝、花药)中异鼠李素-3-O-新橙皮苷、香蒲新苷的含量。结果:草蒲黄为蒲黄花粉、花药及花丝的混合物,呈棕黄色絮状;蒲黄花粉呈黄色粉末,手感细腻,气微,味淡,细胞表面略呈条状;花丝和花药呈丝状、短线状,手感粗涩,表面观细胞呈长条形。草蒲黄、蒲黄花粉及蒲黄杂质的薄层色谱鉴别结果具有一致的色谱斑点;含量测定结果显示,异鼠李素-3-O-新橙皮苷、香蒲新苷及其二者总含量在蒲黄花粉中均最高(分别为0.42%、0.24%、0.64%),草蒲黄其次(0.22%、0.17%、0.39%),筛上杂质中含量最低(0.19%、0.14%、0.33%);草蒲黄与筛上杂质中异鼠李素-3-O-新橙皮苷和香蒲新苷的总含量均未达到2015年版《中国药典》规定含量限度(不得少于0.50%)。结论:蒲黄的药用成分主要存在于花粉中。建议草蒲黄应作为获取花粉的原料,而不宜直接药用。
ABSTRACT: OBJECTIVE:To compare the quality between Stamen typhae and pollen of T. angustifolia ,and provide scientific evidence for the improvement of quality standard of T. angustifolia . METHODS :Fifteen batches of S. typhae were collected. Pollen minus sieve ,impurity plus sieve (filament and anther )were sift out from S. typhae according to the identification method of T. angustifolia in Chinese Pharmacopoeia (2015 edition). The characteristics and components of S. typhae and pollen ,filament and anther of T. angustifolia were comfirmed by impurity , character examination and microscope , TLC. The contents of isorhamnetin-3-O-neohesperidoside and typhaneoside in S. typhae and pollen ,impurities plus sieve (filament and anther )of T. angustifolia were determined by HPLC. RESULTS :S. typhae was a mixture of pollen ,anther and filament of T. angustifolia ,in the form of brownish yellow flocculent. The pollen of S. typhae was yellow powder with delicate hand feel ,slight smell and light taste;the surface of cells was slightly striped. The filaments and anthers were filiform and short-term ,rough and astringent ,and the cell surface were long strip. TLC chromatogram of S. typhae ,pollen and impurity of T. angustifolia had the same color spots at the same location. The contents of isorhamnetin- 3-O-neohesperidoside,typhaneoside and their aggregate were the highest in pollen (0.42%,0.24%,0.64%);the second in S. typhae (0.22%,0.17%,0.39%);the lowest in the impurities plus sieve (0.19%, 0.14%,0.33%). The total contents of isorhamnetin- 3-O-neohesperidoside and typhaneoside in S. typhae and in impurities plus sieve did not reach the content limit stipulated in Chinese Pharmacopoeia (not less than 0.50%). CONCLUSIONS:The medicinal components of T. angustifolia mainly exist in pollen. It is suggested that S. typhae should be used as the raw material to obtain pollen,and should not be used directly.
期刊: 2020年第31卷第07期
作者: 严华,魏锋,马双成
AUTHORS: YAN Hua,WEI Feng,MA Shuangcheng
关键字: 蒲黄;草蒲黄;药用部位;异鼠李素-3-O-新橙皮苷;香蒲新苷;质量标准
KEYWORDS: Typha angustifolia ;Stamen typhae ;Medicinal part ;Isorhamnetin-3-O-neohesperidoside;Typhaneoside;Quality
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