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我国2009－2018年儿童药物经济学研究文献质量评价
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| 篇名： | 我国2009－2018年儿童药物经济学研究文献质量评价 |
| TITLE： | Quality Appraisal of Pediatric Pharmacoeconomic Research Literatures in China from 2009 to 2018 |
| 摘要： | 目的：为提高我国儿童药物经济学研究水平提供参考。方法：以“儿童“”药物经济学“”成本-效果“”成本-效益“”成本-效用“”最小成本”等为关键词，检索中国知网、万方、维普、中国生物医学文献数据库中2009年1月－2018年12月发表的儿童药物经济学研究文献，采用儿童药物经济学质量评价问卷对纳入文献进行质量评价，分析现有文献存在的问题并提出建议。结果与结论：共纳入儿童药物经济学研究文献140篇。发文数量总体呈增长态势，期刊分布松散；第一作者以医疗机构为主，主要涉及呼吸系统疾病以及药物治疗等。其中，15篇研究文献注明了研究角度，109篇研究时限≤1年，6篇进行了敏感性分析，多采用成本-效果分析和决策分析模型。质量评价结果显示，纳入的140篇文献在经济评价、比较方案、目标人群、产出、分析、结论等维度得分较高（0.62～1.00分），时间范围和贴现维度得分一般（分别为0.49分和0.53分），但研究视角、成本和资源使用、增量分析、敏感性分析、利益冲突等维度得分较低（0.10～0.31分）。我国儿童药物经济学研究所存在的问题集中于研究视角选取、成本与临床数据收集测算、分析方法选用等方面。建议《中国药物经济学评价指南》补充儿童药物经济学方法学内容，以指导儿童药物经济学相关研究；同时，相关学者开展儿童药物经济学研究应从明确研究视角、规范成本识别测量方法、合理选择健康产出指标、正确运用分析方法等方面进一步提升其研究质量。 |
| ABSTRACT： | OBJECTIVE：To provide reference for improving the level of pediatric pharmacoeconomic research in China. METHODS： Using “Pediatric”“Pharmacoeconomics”“Cost-effectiveness”“Cost-utility”“Cost-benefit”“Minimum cost ” as keywords，pediatric pharmacoeconomic research literatures published during Jan. 2009 to Dec. 2018 were retrieved from CNKI ， Wanfang，VIP and CBMdisc. The Pediatric Quality Appraisal Questionnaire was used to evaluate the quality of the literatures. The problems of these literatures were analyzed to put forward the suggestions. RESULTS & CONCLUSIONS ：Totally 140 literatures were eventually included. The number of published literatures was increasing and the distrubtion of journals was scattered. The first auther was mainly from medical institutions. Included literatures mainly involved respiratory disease and drug treatment ，etc. Among them ，15 literatures indicated the research angle ；research time limit of 109 literatures was equal to or less than one year ；6 literatures carried out sensitivity analysis. Most of them adopted cost-effectiveness analysis and decision analysis model. The results of quality evaluation showed that the economic evaluation ，camparators，target population ，outcomes，analysis and conclusions domains had high scores （0.62 to 1.00 score），time horizon and discounting domains had middle scroes （0.49 and 0.53 score respectively），but perspective ，costs and resource use ，incremental analysis ，sensitivity analysis and conflict of intrest domains had low scores （0.10 to 0.31 score）. The main problems of pediatric pharmacoeconomic literatures in China focused on selection of research perspective ，measurement of costs and clinical outcomes ，and selection of analytical methods. The quality of pediatric pharmacoeconomic evaluations in China need to improve. It is suggested to supplement the content of pediatric pharmacoeconomics in China Guidelines for Pharmacoeconomic Evaluations . It is also suggested for pediatric pharmacoeconomic evaluations to clarify the perspective ，standardize the cost identification ，reasonably select health outcome indicators and correctly apply analysis method in order to improve the quality. |
| 期刊： | 2020年第31卷第06期 |
| 作者： | 徐蔼琳，李文君，卢梦情，席晓宇 |
| AUTHORS： | XU Ailin，LI Wenjun ，LU Mengqing ，XI Xiaoyu |
| 关键字： | 质量评价；药物经济学；儿童；儿童药物经济学质量评价问卷；中国 |
| KEYWORDS： | Quality appraisal ；Pharmacoeconomics；Pediatric；Pediatric Quality Appraisal Questionnaire ；China |
| 阅读数： | 478 次 |
| 本月下载数： | 15 次 |
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