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分层加权TOPSIS法在某院沙格列汀合理用药评价中的应用
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| 篇名： | 分层加权TOPSIS法在某院沙格列汀合理用药评价中的应用 |
| TITLE： | Application of Hierarchical Weighted TOPSIS to Evaluate Rational Drug Use of Saxagliptin in a Hospital |
| 摘要： | 目的：为科学评价沙格列汀的用药合理性提供方法参考。方法：以沙格列汀的说明书、临床指南、临床路径及相关参考文献为依据，由某院临床内分泌科和药学专家共同商讨制定沙格列汀用药合理性的评价标准，采用层次分析法（AHP）对评价标准的各项指标进行赋权，并通过逼近理想解排序法（TOPSIS法）对该院2018年11月－2019年4月的106份病例资料中沙格列汀的使用情况进行回顾性分析和合理用药评价。结果：共建立了6个一级指标与12个二级指标，指标权重占比较高的前3个指标分别为适应证（权重为0.25）、给药剂量及调整（权重为0.21）、给药频次（权重为0.15）。在106个病例中，合理用药者占比39.6％，基本合理用药者占比51.0％，不合理用药者占比9.4％，且采用加权TOPSIS法所得评价结果与实际情况相符。结论：运用基于AHP加权的TOPSIS法对沙格列汀进行用药合理性评价的方法切实可行。 |
| ABSTRACT： | OBJECTIVE：To provide method reference for scientifically eva luating the rationality of the use of saxagliptin . METHODS：Based on the drug instructions ，clinical guidelines ，clinical pathways ，related references ，clinical endocrinology department and pharmaceutical experts of a hospital jointly discussed and formulated the evaluation criteria for the rationality of the use of saxagliptin. AHP method was used to assign weights to various indexes of evaluation criteria ；TOPSIS method was used to analyze the use of saxagliptin of 106 cases in the hospital during Nov. 2018-Apr. 2019 retrospectively and evaluate rational drug use. RESULTS ：A total of 6 primary indicators and 12 secondary indicators were established. The first three indicators with a relatively high index weight were indications （with a weight of 0.25），dose and adjustment of administration （with a weight of 0.21）and frequency of administration （with a weight of 0.15）. Among 106 cases，39.6％ of drug use were reasonable ，51.0％ were basically reasonable and 9.4％ were unreasonable. Evaluation results made by weighted TOPSIS were consistent with the actual situation. CONCLUSIONS ：TOPSIS method weighted by AHP is reasonable and feasible for evaluating the rationality of saxagliptin use. |
| 期刊： | 2020年第31卷第05期 |
| 作者： | 李燕，沈爱宗，朱鹏里，周婉，方明，倪伟建，魏伟，唐丽琴 |
| AUTHORS： | LI Yan，SHEN Aizong ，ZHU Pengli，ZHOU Wan，FANG Ming，NI Weijian ，WEI Wei，TANG Liqin |
| 关键字： | 沙格列汀；层次分析法；逼近理想解排序法；合理用药评价 |
| KEYWORDS： | Saxagliptin；AHP；TOPSIS method ；Rational evaluation of drug use |
| 阅读数： | 286 次 |
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