不同透皮吸收促进剂对黄绵马酸BB乳膏体外透皮吸收的影响
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篇名: 不同透皮吸收促进剂对黄绵马酸BB乳膏体外透皮吸收的影响
TITLE: Effects of Different Penetration Enhancers on in vitro Transdermal Permeation of Flavaspidic Acid BB Cream
摘要: 目的:研究不同透皮吸收促进剂对黄绵马酸BB乳膏体外透皮吸收的影响。方法:分别制备含1%氮酮、2%氮酮、3%氮酮、4%氮酮、1%薄荷醇、1%丙二醇、1%油酸、1%氮酮+1%薄荷醇、1%氮酮+1%丙二醇、1%氮酮+1%油酸、1%薄荷醇+1%丙二醇等11种不同透皮吸收促进剂的黄绵马酸BB乳膏。采用改良Franz扩散池,以离体雄性大鼠腹部皮肤为透皮屏障,通过超高效液相色谱法测定接受液中黄绵马酸BB含量,并计算24h内的单位面积累积透过量(Q24h)和经皮渗透速率(Jss);同时与无透皮吸收促进剂的黄绵马酸BB乳膏进行比较,计算增渗比(ER)。结果:含上述11种透皮吸收促进剂的黄绵马酸BB乳膏的Q24h分别为(82.96±7.15)、(80.17±0.66)、(78.22±1.87)、(73.53±1.24)、(35.65±2.23)、(34.02±1.73)、(42.68±2.66)、(33.94±1.37)、(34.16±1.54)、(46.78±1.21)、(43.66±1.69)μg/cm2,Jss分别为(5.26±0.10)、(4.69±0.12)、(4.45±0.45)、(4.00±0.06)、(3.74±0.33)、(3.23±0.18)、(3.73±0.53)、(3.14±0.47)、(3.54±0.11)、(3.98±0.34)、(4.34±0.14)μg(/cm2·h),ER分别为2.055、1.831、1.738、1.564、1.462、1.263、1.456、1.227、1.385、1.557、1.698。结论:以上透皮吸收促进剂均可增强黄绵马酸BB乳膏的透皮吸收作用,其中以1%氮酮的作用最强。
ABSTRACT: OBJECTIVE:To study the effects of different penetration enhancers on in vitro transdermal permeation of Flavaspidic acid BB cream. METHODS :Flavaspidic acid BB cream was prepared ,containing 11 kinds of different penetration enhancers as 1% azone,2% azone,3% azone,4% azone,1% menthol,1% propylene glycol ,1% oleic acid ,1% azone+1% menthol,1% azone+1% propanediol,1% azone+1% oleic acid or 1% menthol+1% propanediol. Modified Franz diffusion cell was adopted using abdominal skin of isolated male rat as transdermal barrier. The content of flavaspidic acid BB was determined by UPLC. The accumulative transdermal amount (Q24 h)and percutaneous permeability (Jss)within 24 h were calculated ;and compared with Flavaspidic acid BB cream without transdermal enhancer ,the enhancement ratio (ER)was calculated. RESULTS : Q24 h of Flavaspidic acid BB cream with above 11 kinds of transdermal enhancers were (82.96±7.15),(80.17±0.66),(78.22± 1.87),(73.53±1.24),(35.65±2.23),(34.02±1.73),(42.68±2.66),(33.94±1.37),(34.16±1.54),(46.78±1.21),(43.66±1.69) μg/cm2,respectively. Jss value were (5.26±0.10),(4.69±0.12),(4.45±0.45),(4.00±0.06),(3.74±0.33),(3.23±0.18), (3.73±0.53),(3.14±0.47),(3.54±0.11),(3.98±0.34),(4.34±0.14)μg(/ cm2·h),respectively. ER were 2.055,1.831,1.738, 1.564,1.462,1.263,1.456,1.227,1.385,1.557,1.698,respectively. CONCLUSIONS :All of the above transdermal absorption enhancers can enhance the percutaneous absorption of Flavaspidic acid BB cream ,among which ,1% azone is the best.
期刊: 2020年第31卷第05期
作者: 梁玉婷,刘小赟,潘敬灵,吴小诗,黄晓彤,唐春萍,沈志滨
AUTHORS: LIANG Yuting ,LIU Xiaoyun ,PAN Jingling ,WU Xiaoshi ,HUANG Xiaotong ,TANG Chunping ,SHEN Zhibin
关键字: 黄绵马酸BB乳膏;透皮吸收促进剂;经皮渗透;体外
KEYWORDS: Flavaspidic acid BB cream;Transdermal absorption enhancer ;Transdermal permeability ;in vitro
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