棘白菌素类抗真菌药物预防侵袭性念珠菌血症有效性与安全性
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篇名: 棘白菌素类抗真菌药物预防侵袭性念珠菌血症有效性与安全性
TITLE:
摘要:
摘 要 目的系统评价棘白菌素类抗真菌药物预防侵袭性念珠菌血症的有效性及安全性为临床治疗提供循证参考方法
算机检索PubMedEmbaseMedlineCochrane图书馆中国期刊全文数据库中文科技期刊数据库万方数据检索时限为建库起 20197收集棘白菌素类药物试验组对比常规抗真菌药物两性霉素B及三唑类抗真菌药对照组预防侵袭性念珠菌血 症有效性和安全性的随机对照试验RCT),对符合纳入标准的临床研究进行资料提取并采用Cochrane系统评价员手册5.0.2进行 质量评价后采用Rev Man 5.2 统计软件对突破性侵袭性真菌感染率真菌感染死亡率全因死亡率及因不良反应停药的发生率进 Meta 分析结果共纳入7RCT合计3 219例患者Meta 分析结果显示试验组患者突破性侵袭性真菌感染发生率[OR0.5895CI0.400.85),P=0.004]真菌感染死亡率[OR=0.6895CI0.510.92),P=0.01]和因不良反应停药的发生率[OR0.5295CI0.400.67),P<0.001]均显著低于对照组差异均有统计学意义两组患者全因死亡率比较差异无统计学意义 [OR=0.8495CI0.671.05),P=0.13]结论与两性霉素B及三唑类抗真菌药比较棘白菌素类药物用于预防侵袭性念珠菌血 症可降低突破性侵袭性真菌感染发生率真菌感染死亡率和因不良反应停药的发生率
ABSTRACT:
ABSTRACT OBJECTIVETo systematically evaluate the efficacy and safety of echinococcins in the prevention of invasive
candidiasisand to provide evidence-based reference for clinical treatment. METHODSRetrieved from PubMedEmbase
MedlineCochrane libraryCJFDVIP and Wanfang databaserandomized controlled trialsRCTsabout the effectiveness and safety of echinococcins trial groupversus conventional fungal drugs amphotericin B and triazole antifungal agentscontrol groupin the prevention of invasive candidiasis were collected during database establishment to Jul. 2019. After data extraction of clinical studies met inclusion criteria and quality evaluation with Cochrane system evaluator manual 5.0.2Meta-analysis was performed for breakthrough invasive fungal infection ratefungal infection mortality rateall-cause mortality rate and the incidence of drug withdrawal due to adverse reactions by using Rev Man 5.2 statistical software. RESULTSTotally 7 RCTs were includedinvolving 3 219 patients. Results of Meta-analyses indicated that the incidence of breakthrough invasive fungal infection [OR=0.5895CI0.400.85),P=0.004]fungal infection mortality rate[OR=0.6895CI0.51
0.92),P=0.01] and the incidence of drug withdrawal due to adverse reactions [OR=0.5295CI0.40
0.67),P<0.001] in trial groups were significantly lower than control groupwith statistical significance. There was no statistical significance in the all-cause mortality rate [OR=0.8495CI0.671.05),P=0.13]. CONCLUSIONSCompared with amphotericin B and triazole antifungal agentsechinococcins used for the prevention of invasive candidiasis can reduce the incidence of breakthrough invasive fungal infectionfungal infection mortality rate and the incidence of drug withdrawal due to adverse reactions
期刊: 2020年第31卷第1期
作者: 李 莎,戴立波,姚海涛,孔旭东
AUTHORS: LI Sha,DAI Libo,YAO Haitao,KONG Xudong
关键字: 棘白菌素;预防;侵袭性念珠菌血症;随机对照试验;有效性;安全性;Meta分析
KEYWORDS: Echinococcins; Prevention; Invasive candidiasis;Randomized controlled trials;Efficacy;Safety;Metaanalysis
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