2014-2019 年郑州某儿童医院血流感染病原菌分布及耐药性
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篇名: 2014-2019 年郑州某儿童医院血流感染病原菌分布及耐药性
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摘要:

摘 要 目的分析郑州某儿童医院血流感染病原菌分布及耐药性为临床抗感染治疗合理选择药物提供参考方法采用回顾 性分析方法收集201410-20199月郑州大学附属儿童医院住院患者血培养标本128 318统计分析其阳性率和血流感 染患儿的临床症状及临床诊断使用WHONET 5.6软件统计阳性标本的病原菌菌种送检科室和病原菌对临床主要抗菌药物的 耐药性结果128 318份住院患者血培养标本中阳性率为2.142 746/128 318)。2 746份血培养阳性标本中血流感染患儿主 要症状为发热1 986/2 746),主要临床诊断包括脓毒血症1 679/2 746)、支气管肺炎858/2 746)、化脓性脑膜炎555/2 746);主要 送检科室包括新生儿诊疗中心1 09039.69
[新生儿重症监护室27910.16)、新生儿外科2238.12)、新生 儿内科2097.61)、小婴儿科2007.28及早产儿科1796.52]血液肿瘤科2167.87)、心血管内 2067.50);病原菌为革兰氏阳性菌的占72.80革兰氏阴性菌的占24.21真菌的占2.99在革兰氏阳性菌中
固酶阴性葡萄球菌1 414)、金黄色葡萄球菌146最为常见前者对青霉素G苯唑西林红霉素耐药率均>80后者对青 霉素G红霉素耐药率均>80在革兰氏阴性菌中肺炎克雷伯菌183)、大肠埃希菌172最为常见前者对氨苄西林哌拉 西林氨苄西林/舒巴坦头孢唑啉耐药率均>80后者对氨苄西林四环素耐药率均>80在真菌中白色念珠菌42)、近平 滑念珠菌22最为常见对常用抗真菌药物的耐药率均<10结论该院血流感染病原菌种类复杂以凝固酶阴性葡萄球 肺炎克雷伯菌为主耐药情况严峻
ABSTRACT:
OBJECTIVETo analyze the distribution and drug resistance of bloodstream infection pathogens in a Childrens Hospital from Zhengzhouand to provide reference rational selection of drugs in anti-infective treatment. METHODSBy retrospective analysis128 318 blood culture specimens were collected from inpatients in the Affiliated Childrens Hospital of Zhengzhou University from Oct. 2014 to Sept. 2019. The positive rateclinical symptoms and clinical diagnosis of children with bloodstream infection were analyzed statistically. WHONET 5.6 software was used to analyze pathogenic bacteria of positive specimenthe departments and the resistance of pathogens to the main clinical antibiotics. RESULTSIn 128 318 blood culture samples of inpatientsthe positive rate was 2.142 746/128 318);among 2 746 blood culture positive samplethe main Symptom of childrem with blood stream infection was fever1 986/2 746);main clinical diagnosis included sepsis1 679/2 746), bronchopneumonia858/2 746),purulent meningitis555/2 746. The main departments included neonatal diagnosis and treatment center 1 090 strainsaccounting for 39.69[neonatal intensive care unit 279 strainsaccounting for 10.16),neonatal surgery department 223 strainsaccounting for 8.12),neonatal internal medicine department 209 strainsaccounting for 7.61),infant pediatrics department200 strainsaccounting for 7.28and premature pediatrics department179 strainsaccounting for 6.52]hematology oncology department 216 strainsaccounting for 7.87),cardio vascular medicine department206 strainsaccounting for 7.50. Gram-positive bacteria accounted for 72.80Gram-negative bacteria 24.21fugus 2.99. Among Gram-positive bacteriacoagulase negative staphylococcus1 414 strainsand Staphylococcus aureus146 strainswere the most common. The resistance rate of the former to penicillin Goxacillin and erythromycin was more than 80and that of the latter to penicillin G and erythromycin was more than 80. Among Gram-negative bacteriaKlebsiella pneumoniae 183 strainsand Escherichia coli 172 strainswere the most common. The resistance rates of the former to ampicillinpiperacillinampicillin/sulbactam and cefazolin were more than 80and the latter to ampicillin and tetracycline were more than 80. Among the fungusCandida albicans42 strainsand Candida parapsilosis22 strainswere the most commonand the resistance rate to common antifungal drugs was less than 10. CONCLUSIONSThe pathogens of bloodstream infection in the hospital are complexmainly coagulase negative staphylococcus and K. pneumoniaeand the drug resistance is severe.
期刊: 2020年第31卷第1期
作者: 方盼盼,杨俊文,高凯杰,杨俊梅,孙红启,王颍源
AUTHORS: FANG Panpan,YANG Junwen,GAO Kaijie,YANG Junmei,SUN Hongqi,WANG Yingyuan
关键字: 儿童医院;血流感染;病原菌;耐药性
KEYWORDS: Children hospital;Bloodstream infection;Pathogen;Drug resistance
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