中医辨证个体化疗法治疗胃癌前病变的临床观察
x

请在关注微信后,向客服人员索取文件

篇名: 中医辨证个体化疗法治疗胃癌前病变的临床观察
TITLE:
摘要: 目的:为临床治疗胃癌前病变提供参考。方法:选择2018年1-12月在我院治疗的胃癌前病变患者共685例,其中治疗组455例患者采用中医辨证的个体化中医药物治疗,7 d为1个疗程,共治疗4个疗程;对照组230例患者接受叶酸片治疗,每次5 mg,tid,连续用药2个月。比较两组患者接受治疗前后胃蛋白酶原比值(PGⅠ/PGⅡ)、胃泌素17(G-17)、幽门螺杆菌(Hp)水平的变化情况,以及相关不良反应的发生情况。结果:治疗后,治疗组患者总有效率为90.3%,显著高于对照组的68.6%;治疗组患者的PGⅠ/PGⅡ较治疗前显著上升,且显著高于对照组;两组患者的G-17水平均较治疗前显著下降(P<0.05),而两组患者Hp水平治疗前后比较差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:中医辨证个体化治疗方案可显著延缓胃癌前病变的发展,且安全性良好。
ABSTRACT: OBJECTIVE: To provide reference for clinical treatment of precancerous lesions of gastric cancer. METHODS: A total of 685 patients with precancerous lesions of gastric cancer were selected from our hospital during Jan.-Dec. 2018. Totally 455 patients in treatment group received individualized TCM therapy according to syndrome differentiation, 7 days as a course, 4 courses in total; another 230 patients in control group received Folic acid tablets, 5 mg, tid, for 2 months. The changes of pepsinogen ratio (PGⅠ/PGⅡ), gastrin-17 (G-17) and Helicobacter pylori (Hp)before and after treatment, and the occurrence of ADR were compared between 2 groups. RESULTS: After treatment, total response rate of treatment group was 90.3%, which was significantly higher than 68.6% of control group. PGⅠ/PGⅡ of treatment group were increased significantly, which was significantly higher than control group; G-17 levels of 2 groups were decreased significantly (P<0.05); there was no statistical significance in Hp level between 2 groups before and after treatment (P>0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS: Chinese medicine syndrome differentiation individual therapy can significantly delay the development of precancerous lesions of gastric cancer, and has good safety.
期刊: 2019年第30卷第24期
作者: 梁静秋,谭婧宇,陈琪,王维,张海燕
AUTHORS: LIANG Jingqiu,TAN Jingyu,CHEN Qi,WANG Wei,ZHANG Haiyan
关键字: 中医辨证;胃癌前病变;胃蛋白酶原比;胃泌素17;幽门螺杆菌
KEYWORDS: Chinese medicine syndrome differentiation; Precancerous lesion of gastric cancer; Pepsinogen ratio; Gastrin-17; Helicobacter pylori
阅读数: 101 次
本月下载数: 5 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!