灰色关联度法优化葵花盘“精准炮制”饮片的加工炮制一体化工艺
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篇名: 灰色关联度法优化葵花盘“精准炮制”饮片的加工炮制一体化工艺
TITLE:
摘要: 目的:优化葵花盘“精准炮制”饮片的产地加工炮制一体化工艺。方法:分别以芦丁、牛血清白蛋白为对照品,采用紫外分光光度法测定葵花盘样品中的总黄酮和总蛋白含量;参考《中国药典》方法测定样品中水溶性浸出物、稀乙醇浸出物、乙酸乙酯浸出物的含量。基于与原药材保持质量一致性、偏于抗痛风治疗和偏于平肝止痛等不同需要,分别以总黄酮、总蛋白含量以及3种不同极性浸出物含量为指标,利用灰色关联度法优化3种葵花盘“精准饮片”的加工炮制一体化工艺。结果:灰色关联度分析结果显示,60 ℃烘干块状饮片与原药材以及偏用于平肝止痛饮片的理想样本序列关联度最大;阴干块状饮片与偏用于抗痛风治疗的理想样本序列关联度最大。结论:可针对不同需求采用不同的葵花盘一体化“精准炮制”工艺,如需与原药材保持质量一致性或需要制备偏于平肝止痛的葵花盘饮片,则可采取切块、60 ℃烘干的工艺;如需要制备用于抗痛风治疗的葵花盘饮片,则可采取切块、阴干的工艺。
ABSTRACT: OBJECTIVE: To optimize the integrated processing technology for “precise decoction pieces” of Helianthus annuus. METHODS: The contents of total flavonoids and total protein in H. annuus were determined by UV spectrophotometry with rutin and bovine serum albumin as control. Refering to Chinese Pharmacopoeia, the contents of water soluble extract, dilute ethanol extracts and ethyl acetate extract were determined. Based on the different needs such as maintaining quality consistency with the original medicinal materials, preference for anti-gout treatment, preference for liver calming and pain relief, using the contents of total flavonoids, total protein and 3 kinds of polar extract as indexes, gray correlation method was used to optimize the integrated processing technology of 3 kinds of “precise decoction pieces” of H. annuus. RESULTS: Gray correlation analysis showed that the ideal sample sequence of decoction pieces in massive shape dried at 60 ℃ with the original medicinal materials and decoction pieces with preference use of liver calming and pain relief was the most relevant; the ideal sample sequence of ideal sample sequence of decoction pieces in massive shape dried in the shade with decoction pieces with clinical application preference of anti-gout therapy was the most relevant. CONCLUSIONS: Different integrated processing technology for “precise decoction pieces” of H. annuus can be adopted for different needs. If it is necessary to keep the quality consistent with the original medicinal materials or to prepare H. annuus decoction pieces for liver calming and pain relieving, medicinal material can be cut into massive shape and dried at 60 ℃; if it is necessary to prepare H. annuus decoction pieces for anti-gout treatment, cutting into massive shape and drying in the shade can be adopted.
期刊: 2019年第30卷第24期
作者: 刘吉爽,段连政,徐文慧,常丽静,姜柔齐,宫喜艳,陈新,邱智东
AUTHORS: LIU Jishuang,DUAN Lianzheng,XU Wenhui,CHANG Lijing,JIANG Rouqi,GONG Xiyan,CHEN Xin,QIU Zhidong
关键字: 葵花盘;总黄酮;总蛋白;一体化工艺;精准炮制;灰色关联度
KEYWORDS: Helianthus annuus; Total flavonoids; Total protein; Integrated technology; Precise processing; Gray correlation
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