我院新生儿口服片剂分剂量使用情况调查及对策分析
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篇名: 我院新生儿口服片剂分剂量使用情况调查及对策分析
TITLE:
摘要: 目的:调查我院新生儿科常需分剂量口服的片剂品种及使用频率,探讨片剂分剂量的可行性方案,为临床精准化、个性化用药提供参考。方法:调取我院2017年7月1日-2018年11月30日新生儿内、外科住院患儿使用片剂品种的全部处方,分析各片剂分剂量使用的频次,检索有关片剂分剂量的文献报道,对常需分剂量的口服片剂的溶解性、稳定性及推荐分法进行分析,并提出建议。结果:本次调查共涉及常需分剂量的口服片剂有16个品种,共计分剂量达2 149频次。分剂量使用频次排前3名的品种分别为维生素B2、左甲状腺素钠片、熊去氧胆酸片,占分剂量总频次的80.3%;经查阅文献后制订了分剂量方案的实施流程,并总结了常用分剂量片剂的分劈方法,同时建议临床应通过综合评价片剂和患儿的特点来决定片剂分剂量方案。结论:片剂分剂量在我院新生儿科临床普遍存在,本文总结的将片剂临时调配成口服液体型药品的方法可在必要时为药师提供参考,以满足临床个体化的用药需求。
ABSTRACT: OBJECTIVE: To investigate the variety and frequency of oral tablets splitting commonly used in pediatrics of children’s hospital, and to explore the feasible scheme of tablet splitting, so as to provide the basis for clinical precision and individuation of drug use. METHODS: From 1st Jul. 2017 to 30th Nov. 2018, all the prescriptions of tablet varieties used for neonates hospitalized in internal and surgical departments in our hospital were obtained. The frequency of each tablet splitting was analyzed, and the literature reports of the tablets splitting were searched. The solubility, stability and recommended method of oral tablets splitting were analyzed, and the suggestion were made. RESULTS: In this study, there were 16 kinds of oral tablets that often needed to be divided into different doses, with a total frequency of 2 149 times. Vitamin B2, Levothyroxine sodium tablets and Ursodeoxycholic acid tablets ranked the top three in terms of dose splitting frequency, accounting for 80.3% of the total dosing cases. After consulting the literature, the implementation process of the dosage division scheme was formulated, and the splitting methods of commonly used tablets were summarized. It is suggested that clinical evaluation of tablet and patient characteristics should be taken to determine tablet dosing splitting plan. CONCLUSIONS: Tablet dosing splitting is common in neonatal medication in our hospital. The methods of temporary dispensing tablet into oral liquid drugs summarized in this paper can provide references when necessary to meet the needs of clinical individualized drug use.
期刊: 2019年第30卷第21期
作者: 彭静,王楹,杜兆松,徐华
AUTHORS: PENG Jing,WANG Ying,DU Zhaosong,XU Hua
关键字: 新生儿;口服片剂;分剂量;调查;文献
KEYWORDS: Newborn; Oral tablet; Splitting; Investigation; Literature
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