生姜油微囊的制备及其质量评价
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篇名: 生姜油微囊的制备及其质量评价
TITLE:
摘要: 目的:制备生姜油微囊并对其进行质量评价。方法:以辛烯基琥珀酸淀粉钠为囊材,采用喷雾干燥法制备生姜油微囊。以囊材与囊芯的混合温度、囊材与囊芯质量比、搅拌速度为考察因素,包封率为评价指标,采用正交试验优化生姜油微囊的制备工艺,并对其载药量、包封率、外观、粒径分布及光、热、湿稳定性(以碘价、过氧化值为指标)进行评价。结果:生姜油微囊的最优制备工艺为囊材与囊芯的混合温度60 ℃、囊材与囊芯质量比10 ∶ 1、搅拌速度12 000 r/min。最优工艺所制生姜油微囊的平均载药量为17.97%(n=3)、平均包封率为73.57%(n=3),生姜油微囊形态圆整光滑、无粘连、粒径分布均匀,平均粒径为(6.30±0.27) μm,在光、热、湿条件下生姜油微囊碘价、过氧化值变化较小。结论:优化后的生姜油微囊制备工艺简单、重复性好,生姜油微囊的包封率及载药量高,且稳定性较好。
ABSTRACT: OBJECTIVE: To prepare Zingiber officinale oil microcapsules and to evaluate its quality. METHODS: Z. officinale oil microcapsules were prepared by spray drying method with sodium starch octenyl succinate as capsule material. The preparation technology was optimized by orthogonal test with mixing temperature of capsule material and capsule core, mass ratio of capsule material and capsule core, stirring speed as factors, using encapsulation efficiency as index. The drug loading, encapsulation efficiency, appearance, particle size distribution and stability of light, heat and humidity (using iodine value and peroxide value as indexes) were evaluated. RESULTS: The optimal preparation technology of Z. officinale oil microcapsules was that the mixing temperature of capsule material and core was 60 ℃; mass ratio of capsule material and capsule core was 10 ∶ 1; stirring speed was 12 000 r/min. Average drug-loading amount and encapsulation efficiency of Z. officinale oil microcapsules prepared by optimal technology were 17.97% and 73.57% (n=3). The morphology of Z. officinale oil microcapsules was round, smooth, non-sticky and uniform in size distribution. The average diameter of microcapsules was (6.30±0.27) μm. Under light, heat and humidity conditions, the iodine value and peroxide value of Z. officinale oil microcapsules changed slightly. CONCLUSIONS: The optimal preparation technology of Z. officinale oil microcapsules is simple and reproducible. The prepared microcapsules have good encapsulation efficiency, high drug loading amount and good stability.
期刊: 2019年第30卷第21期
作者: 范贤哲,何福林,刘小文,吕敬崑,陈小明
AUTHORS: FAN Xianzhe,HE Fulin,LIU Xiaowen,LYU Jingkun,CHEN Xiaoming
关键字: 生姜油;微囊;喷雾干燥法;包封率;制备工艺;质量评价
KEYWORDS: Zingiber officinale oil; Microcapsule; Spray drying method; Encapsulation efficiency; Preparation technology; Quality evaluation
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