蓝芩口服液治疗儿童疱疹性咽峡炎有效性与安全性的Meta分析
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篇名: 蓝芩口服液治疗儿童疱疹性咽峡炎有效性与安全性的Meta分析
TITLE:
摘要: 目的:系统评价蓝芩口服液治疗儿童疱疹性咽峡炎的疗效和安全性。方法:计算机检索PubMed、Embase、中国生物医学文献数据库、中国知网、万方数据库、维普数据库等,收集蓝芩口服液或常规对症治疗联合蓝芩口服液(试验组)对比常规对症治疗(对照组)用于儿童疱疹性咽峡炎的随机对照试验(RCT)。筛选文献、提取资料后按Cochrane系统评价员手册5.1.0评价纳入文献的质量,采用Rev  Man 5.3软件进行Meta分析。结果:共纳入11篇RCT,共计1 204例患者。Meta分析结果显示,试验组患儿总有效率显著高于对照组 [RR=1.17,95%CI(1.10,1.24),P<0.000 01]、疱疹消退时间 [MD=-2.17,95%CI(-2.63,-1.72),P<0.000 01]、发热消退时间[MD=-1.52,95%CI(-1.72,-1.31),P<0.000 01]均显著短于对照组;两组患儿不良反应发生率比较差异无统计学意义[RR=1.00,95%CI(0.52,1.93),P=1.00]。按是否给予补液对症处理进行的亚组分析显示,未给予补液对症处理,试验组患儿疱疹消退时间显著短于对照组[MD=-1.64,95%CI(-2.03,-1.26),P<0.000 01];给予补液对症处理,试验组患儿疱疹消退时间显著短于对照组 [MD=-2.79,95%CI(-2.97,-2.61),P<0.000 01]。结论:蓝芩口服液可显著提高疱疹性咽峡炎患儿的疗效,有效缩短疱疹消退时间和发热消退时间,且未增加不良反应的发生。
ABSTRACT: OBJECTIVE: To systematically evaluate the efficacy and safety of Lanqin oral liquid in the treatment of herpangina in children. METHODS: Randomized controlled trials (RCTs) involving Lanqin oral liquid or routine symptomatic treatment combined with Lanqin oral liquid (trial group) versus routine treatment (control group) in the treatment of pediatric herpangina were retrieved  from PubMed, Embase, CBM, CNKI, Wanfang database, VIP database, etc. Meta-analysis was performed by using Rev Man 5.3 software after literature screening, data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0. RESULTS: A total of 11 RCTs were included, involving 1 204 patients. Meta-analysis showed that total response rate [RR=1.17, 95%CI(1.10, 1.24), P<0.000 01], fade time of herpes [MD=-2.17, 95%CI(-2.63, -1.72), P<0.000 01] and fade time of fever [MD=-1.52, 95%CI(-1.72, -1.31), P<0.000 01] in trial group was significantly higher than in control group. There was no statistical significance in the incidence of ADR between 2 groups [RR=1.00, 95%CI(0.52, 1.93), P=1.00]. Subgroup analysis based on rehydration symptomatic treatment showed that without rehydration, fade time of herpes in trial group was significantly shorter than control group [MD=-1.64, 95%CI (-2.03, -1.26), P<0.000 01]; with rehydration, fade time of herpes in trial group was significantly shorter than control group [MD=-2.79, 95%CI(-2.97, -2.61),P<0.000 01]. CONCLUSIONS: Lanqin oral liquid can effectively improve therapeutic efficacy of herpangina patients, effectively shorten fade time of fever and herpes, without increasing the occurrence of ADR.
期刊: 2019年第30卷第12期
作者: 袁斌,孙亚磊,武祎文,许少菊
AUTHORS: YUAN Bin,SUN Yalei,WU Yiwen,XU Shaoju
关键字: 蓝芩口服液;儿童;疱疹性咽峡炎;疗效;安全性;Meta分析
KEYWORDS: Lanqin oral liquid; Children; Herpangina; Efficacy; Safety; Meta-analysis
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