局部应用抗青光眼药物致患者干眼症发生的影响因素分析
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篇名: 局部应用抗青光眼药物致患者干眼症发生的影响因素分析
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摘要: 目的:了解局部应用抗青光眼药物致患者干眼症的发生情况及其影响因素,为青光眼患者干眼症的防治提供参考。方法:选取2015年6月-2018年6月我院就诊的600例接受抗青光眼局部用药治疗的患者作为研究对象,对患者进行眼科检查及问卷调查,对致干眼症发生的影响因素进行单因素分析及多因素Logistic回归分析。结果:本次共发放调查问卷600份,收回547份,回收率为91.17%。收回问卷的547例患者中有36例拒绝接受进一步检查,19例被剔除,共492例纳入研究。在492例接受抗青光眼局部用药治疗的患者中,干眼症患者为262例,总患病率为53.25%;干眼症状出现频率前3位为干涩感、烧灼感、异物感,分别有182例(69.47%)、159例(60.69%)、106例(40.46%)。单因素分析结果显示,不同性别、年龄、使用视频终端时长、干燥环境、用药时间、用药种类、用药频次以及睡眠质量是否良好、药物有无传统防腐剂、有无翼状胬肉、有无睑板腺功能障碍患者发生干眼症的比例组间比较差异均有统计学意义(P<0.05)。多因素Logistic 回归分析结果显示,患者性别、用药时间、用药种类、药物有无传统防腐剂、睑板腺功能障碍、使用视频终端等为青光眼药物治疗患者干眼症发生的危险因素(OR为1.613~2.477)。结论:接受抗青光眼局部药物治疗的患者干眼症发生率较高,医师应针对性别、用药时间、用药种类、药物有无传统防腐剂、睑板腺功能障碍、使用视频终端等危险因素做好防治措施,最大限度地缓解干眼症患者的眼部不适,从而提高青光眼患者治疗依从性。
ABSTRACT: OBJECTIVE: To investigate the occurrence and influencing factors of dry eye in patients with topical use of anti-glaucoma drugs, and to provide reference for the prevention and treatment of dry eye in glaucoma patients. METHODS: Totally 600 patients receiving topical use of anti-glaucoma drugs were selected from our hospital as research objects during Jun. 2015 to Jun. 2018. The ophthalmologic examination and questionnaire survey were carried out. The univariate analysis and multivariate Logistic regression analysis were conducted for influencing factors of dry eye. RESULTS: A total of 600 questionnaires were distributed and 547 questionnaires were recovered, with a recovery rate of 91.17%. Of the 547 patients who withdrew the questionnaire, 36 patients refused to undergo further examination, 19 patients were excluded, and a total of 492 patients were included in the study.Of 492 patients treated with topical anti-glaucoma drugs, there were 262 dry eye patients with incidence of 53.25%. Top 3 symptoms of dry eye were dryness, burning and foreign body sensation, involving 182 cases (69.47%), 159 cases (60.69%) and 106 cases (40.46%). The results of univariate analysis showed that there was statistical significance in the difference of gender, age, sleep quality, use of video display terminals, dry environment, medication time, medication types, medication frequency, medication with or without traditional preservatives, pterygium, tarsal gland dysfunction between 2 groups (P<0.05). Multivariate Logistic regression analysis showed that gender, medication time, medication type, medication with or without traditional preservatives, tarsal gland dysfunction and video display terminals were risk factors for the occurrence of dry eye in glaucoma patients (OR were 1.613-2.477). CONCLUSIONS: The incidence of dry eye in patients treated with topical use of anti-glaucoma drug is high. The clinicians should take the prevention and treatment measures according to its risk factors, such as gender, medication time, medication type, medication with or without traditional preservatives, tarsal gland dysfunction and video display terminals, and minimize ocular discomfort in patients with dry eyes so as to improve the therapeutic compliance of glaucoma patients.
期刊: 2019年第30卷第10期
作者: 王琛,王丽,武蓓,宫瑞中
AUTHORS: WANG Chen,WANG Li,WU Bei,GONG Ruizhong
关键字: 青光眼;抗青光眼药物;干眼症;影响因素
KEYWORDS: Glaucoma; Anti-glaucoma drug; Dry eye; Influencing factors
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