利奈唑胺致血小板减少危险因素的Meta分析
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篇名: 利奈唑胺致血小板减少危险因素的Meta分析
TITLE:
摘要: 目的:系统评价利奈唑胺致血小板减少的危险因素,为临床合理用药提供参考。方法:计算机检索PubMed、Embase、Cochrane图书馆、Web of Science、中国生物医学文献数据库、中国知网和万方数据,检索时限均为建库起至2018年10月,收集利奈唑胺致血小板减少危险因素的临床研究,对符合标准的文献进行资料提取,并采用纽卡斯尔-渥太华质量评估量表(NOS)对纳入文献进行质量评价后,采用Rev Man 5.3软件进行Meta分析。结果:共纳入16项临床研究,合计2 264例患者。Meta分析结果显示,日公斤剂量高[SMD=0.62,95%CI(0.29,0.95),P=0.000 2]、用药前血小板计数低[SMD=-0.90,95%CI(-1.62,-0.18),P=0.01]、肌酐清除率低 [SMD=-0.65,95%CI(-1.10,-0.19),P=0.005]、疗程长 [SMD=0.45,95%CI(0.18,0.71),P=0.000 9]、体质量低 [SMD=-0.36,95%CI(-0.60,-0.11),P=0.005]对血小板减少的发生均有显著影响。结论:血小板基础值低、肌酐清除率低、体质量低,用药疗程长和日公斤剂量高是利奈唑胺致血小板减少的危险因素。
ABSTRACT: OBJECTIVE: To evaluate risk factors of linezolid-induced thrombocytopenia systematically, and to provide reference for rational drug use in clinic. METHODS: Retrieved from PubMed, Embase, Cochrane library, Web of Science, CBM, CNKI and Wanfang database, during database establishment to Oct. 2018, clinical studies about risk factors of linezolid-induced thrombocytopenia were collected, and the data of literatures met criteria were collected. After Newcastle-Ottawa scale (NOS) was applied for evaluating the quality of included literatures. Meta-analysis was conducted by using Rev Man 5.3 software. RESULTS: Sixteen clinical studies involving 2 264 patients in total were included. Results of Meta-analysis showed that daily per kg dose (DKPD) [SMD=0.62, 95%CI(0.29,0.95), P=0.000 2], low platelet count before medication [SMD=-0.90, 95%CI(-1.62, -0.18), P=0.01], low creatinine clearance rate [SMD=-0.65, 95%CI(-1.10,-0.19), P=0.005], long treatment course [SMD=0.45, 95%CI(0.18,0.71), P=0.000 9], low body weight  [SMD=-0.36, 95%CI(-0.60,-0.11),P=0.005] significantly influenced the occurrence of thrombocytopenia. CONCLUSIONS: The risk factors associated with linezolid-induced thrombocytopenia include low baseline platelet count, low creatinine clearance rate, low body weight, long medication course and high DKPD.
期刊: 2019年第30卷第7期
作者: 白浩,孙朴,陈开杰
AUTHORS: BAI Hao,SUN Pu,CHEN Kaijie
关键字: 利奈唑胺;血小板减少;危险因素;Meta分析
KEYWORDS: Linezolid; Thrombocytopenia; Risk factors; Meta-analysis
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