局部应用前列腺素类似物滴眼液对原发性开角型青光眼患者角膜厚度影响的Meta分析
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篇名: 局部应用前列腺素类似物滴眼液对原发性开角型青光眼患者角膜厚度影响的Meta分析
TITLE:
摘要: 目的:系统评价局部应用前列腺素类似物滴眼液对原发性开角型青光眼患者角膜厚度的影响,为临床用药提供循证参考。方法:计算机检索Cochrane图书馆、PubMed、Embase、Medline、中国知网、维普数据库、中国生物医学文献数据库和万方数据库等,收集前列腺素类似物滴眼液(试验组)对比常规治疗药物或安慰剂(对照组)对原发性开角型青光眼患者角膜厚度影响的随机对照试验(RCT),提取资料并按Cochrane系统评价员手册5.2中的工具评价文献质量后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入6项RCT,合计527例患者。Meta分析结果显示,两组患者中央角膜厚度[MD=-13.63,95%CI(-28.50,1.23),P=0.07]、顶端角膜厚度[MD=-7.53,95%CI(-19.46,4.40),P=0.22]、最薄角膜厚度[MD=-5.87,95%CI(-17.69,5.95),P=0.33]、眼压[MD=-5.44,95%CI(-14.90,4.02),P=0.26]比较,差异均无统计学意义。结论:前列腺素类似物滴眼液对原发性开角型青光眼患者的角膜厚度无显著影响。
ABSTRACT: OBJECTIVE: To systematically evaluate the effects of topical application of Prostaglandin eye drops on corneal thickness in patients with primary open-angle glaucoma, and to provide evidence-based reference in clinic. METHODS: Retrieved from Cochrane library, PubMed, EMbase, Medline, CNKI, VIP, CBM and Wanfang database, randomized controlled trials (RCTs) about the effects of Prostaglandin eye drops (trial group) and conventional drug or placebo (control group) on corneal thickness were collected. After data extraction and quality evaluation with Cochrane Systematic Reviewer Manual 5.2, Meta-analysis was performed by using Rev Man 5.3 software. RESULTS: A total of 6 RCTs were included, involving 527 patients. The results of Meta-analysis showed that there was no statistical significance in central corneal thickness [MD=-13.63,95%CI(-28.50,1.23), P=0.07], apical cornea thickness [MD=-7.53,95%CI(-19.46,4.40), P=0.22], thinnest corneal thickness [MD=-5.87,95%CI(-17.69,5.95), P=0.33] or intraocular pressure [MD=-5.44,95%CI(-14.90,4.02), P=0.26] between 2 groups. CONCLUSIONS: Prostaglandin eye drops have no significant effect on corneal thickness in patients with primary open-angle glaucoma.
期刊: 2018年第29卷第24期
作者: 蒋鹏飞,李怡琛,彭清华,陈向东
AUTHORS: JIANG Pengfei,LI Yichen,PENG Qinghua,CHEN Xiangdong
关键字: 前列腺素类似物滴眼液;原发性开角型青光眼;Meta分析;中央角膜厚度;顶端角膜厚度;最薄角膜厚度;眼压;影响
KEYWORDS: Prostaglandin eye drops; Primary open-angle glaucoma; Meta-analysis; Central corneal thickness; Apical cornea thickness; Thinnest corneal thickness; Intraocular pressure; Effects
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