消渴方治疗气阴两虚型2型糖尿病疗效的Meta分析
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篇名: 消渴方治疗气阴两虚型2型糖尿病疗效的Meta分析
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摘要: 目的:系统评价消渴方治疗气阴两虚型2型糖尿病(T2DM)的疗效,为临床提供循证参考。方法:计算机检索PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库、中国期刊全文数据库等,纳入消渴方加减(试验组)对比二甲双胍片或胰岛素等药物(对照组)治疗气阴两虚型T2DM的随机对照试验(RCT)。筛选文献、提取资料并按照改良的Jadad评分量表评价纳入研究质量后,采用Rev Man 5.3统计软件对数据进行Meta分析。结果:共纳入18项RCT,合计2 065例患者。Meta分析结果显示,试验组患者总有效率[OR=2.89,95%CI(2.16,3.86),P<0.001]显著高于对照组,空腹血糖[SMD=-0.72,95%CI(-0.96,-0.47),P<0.001]、餐后2 h血糖[SMD=-0.72,95%CI(-0.96,-0.47),P<0.001]、糖化血红蛋白[MD=-0.65,95%CI(-0.88,-0.42),P<0.001]、中医证候积分[MD=-5.77,95%CI(-7.46,-4.08),P<0.001]均显著低于对照组。纳入的18项RCT共涉及方剂18首,共包含66味药材,各药材的使用频次总和为218;其中,使用频率较高的为天花粉、黄连、麦冬等。结论:消渴方治疗气阴两虚型T2DM的疗效显著,可有效降低相关指标水平及中医证候积分。
ABSTRACT: OBJECTIVE: To systematically evaluate therapeutic efficacy of Xiaoke formula in the treatment of type 2 diabetes mellitus (T2DM) with Qi and Yin deficiency, and to provide evidence-based reference in clinic. METHODS: Retrieved from PubMed, Embase, Cochrane Library, CBM and CNKI, randomized controlled trials (RCTs) about modified Xiaoke formula (trial group) with Qi and Yin deficiency versus Metformin tablet or insulin (control group) in the treatment of T2DM were included. After literature screening and data extraction, the qualities of included studies were evaluated by modified Jadad scoring scale. Meta-analysis was performed by using Rev Man 5.3 statistical software. RESULTS: Totally 18 RCTs were included, involving      2 065 patients. Meta-analysis showed that response rate of trial group [OR=2.89, 95%CI(2.16,3.86), P<0.001] was significantly higher than that of control group, while fasting blood glucose [SMD=-0.72, 95%CI(-0.96,-0.47), P<0.001], 2 h postprandial blood glucose [SMD= -0.72, 95%CI(-0.96,-0.47), P<0.001], glycosylated hemoglobin [MD=-0.65, 95%CI(-0.88,-0.42), P<0.001] and TCM syndrome score [MD=-5.77, 95%CI(-7.46,-4.08), P<0.001] were significantly lower than control group. Totally 18 RCTs were included, involving 18 formula and 66 ingredients. The sum of use frequency of various medicinal materials was 218. Trichosanthes, Coptis chinensis, Ophiopogon japonicus and so on were used most frequently. CONCLUSIONS: Xiaoke formula shows significant therapeutic efficacy for T2DM with Qi and Yin deficiency, and reduces related index levels and TCM syndrome score effectively.
期刊: 2018年第29卷第20期
作者: 张蔚,雷鸣
AUTHORS: ZHANG Wei,LEI Ming
关键字: 消渴方;气阴两虚型;2型糖尿病;疗效;Meta分析
KEYWORDS: Xiaoke formula; Qi and Yin deficiency; Type 2 diabetes mellitus; Therapeutic efficacy; Meta-analysis
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