恒古骨伤愈合剂对绝经后骨质疏松和骨质疏松性骨折模型树鼩体成分的影响
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篇名: 恒古骨伤愈合剂对绝经后骨质疏松和骨质疏松性骨折模型树鼩体成分的影响
TITLE:
摘要: 目的:研究恒古骨伤愈合剂对绝经后骨质疏松(OP)和骨质疏松性骨折(OPF)模型树鼩体成分的影响。方法:将50只雌性滇西亚种树鼩随机分为正常对照组(等体积0.9%氯化钠溶液)、OP模型组(等体积0.9%氯化钠溶液)、OP用药组(3 mL/kg)、OPF模型组(等体积0.9%氯化钠溶液)、OPF用药组(3 mL/kg),每组10只。切除树鼩双侧卵巢和子宫以建立OP模型;取OP模型树鼩行右侧后肢胫骨骨折术以建立OPF模型。建立OP模型180 d后/建立OPF模型成功后,灌胃相应药物,每2 d 1次,连续90 d。给药90 d后以双能X线吸收法检测树鼩全身及各部位的体成分。结果:与正常对照组比较,OP模型组树鼩全身(含头部和不含头部)骨矿盐含量均显著减少,肌肉组织百分比均显著降低,脂肪组织百分比均显著升高;脊柱、腰椎、腰骶骨、骨盆骨面积均显著增加,肌肉组织百分比均显著降低,脂肪组织百分比均显著升高;左骨盆、右骨盆肌肉组织百分比均显著降低,脂肪组织百分比均显著升高,差异均有统计学意义(P<0.05或P<0.01)。与OP模型组比较,OP用药组树鼩全身(含头部)脂肪组织百分比显著降低;全身(不含头部)骨矿盐含量显著增加,脂肪组织百分比显著降低;脊柱、腰椎、腰骶骨、骨盆骨面积均显著减少,肌肉组织百分比均显著升高,脂肪组织百分比均显著降低;左骨盆、右骨盆肌肉组织百分比均显著升高,脂肪组织百分比均显著降低,差异均有统计学意义(P<0.05或P<0.01)。与正常对照组比较,OPF模型组树鼩全身(含头部和不含头部)、脊柱、腰椎骨矿盐含量均显著减少,脂肪组织百分比均显著升高;骨盆骨矿盐含量显著减少,肌肉组织百分比显著降低,脂肪组织百分比均显著升高;腰骶骨、左骨盆、右骨盆脂肪组织百分比均显著升高,差异均有统计学意义(P<0.05或P<0.01)。与OPF模型组比较,OPF用药组树鼩全身(含头部和不含头部)、脊柱、骨盆肌肉组织百分比均显著升高,脂肪组织百分比均显著降低;腰椎、腰骶骨、左骨盆、右骨盆脂肪组织百分比均显著降低,差异均有统计学意义(P<0.05或P<0.01)。结论:恒古骨伤愈合剂对绝经后OP和OPF模型树鼩的体成分有一定改善作用。
ABSTRACT: OBJECTIVE: To study the effects of Osteoking on body composition of osteoporosis (OP) and osteoporotic fracture (OPF) model tree shrews after menopause. METHODS: Fifty western Yunnan female tree shrews were randomly divided into normal control group (constant volume of 0.9% sodium chloride solution), OP model group (constant volume of 0.9% sodium chloride solution), OP medication group (3 mL/kg), OPF model group (constant volume of 0.9% sodium chloride solution), and OPF medication group (3 mL/kg), with 10 tree shrews in each group. OP model was induced by resecting bilateral ovaries and uterus. OPF model was induced by receiving tibial fracture of right hind limb. 180 d after inducing OP model/after inducing OPF model,those were given relevant medicine intragastrically, every 2 days, for consecutive 90 d. 90 d after inducing model, dual energy X-ray absorptiometry was used to detect body composition in the whole body and various parts of tree shrews. RESULTS: Compared with normal control group, the content of bone mineral salt and the percentage of muscle tissue in the whole body of tree shrews (including head,excluding head) decreased significantly in OP model group, while the percent of adipose tissue were increased significantly; bone area of vertebrae, lumbar vertebrae, lumbosacral, pelvis was increased significantly, the percentage of muscle tissue decreased significantly, while the percent age of adipose tissue were increased significantly; the percentage of muscle tissue in left pelvis and right pelvis decreased significantly, while the percentage of adipose tissue were incresed significantly, with statistical significance (P<0.05 or P<0.01). Compared with OP model group, the percent age of adipose tissue in the whole body of tree shrews (including head) decreased significantly in OP medication group; the content of bone mineral salt in the whole body of tree shrews (excluding head) increased significantly, while the percent age of adipose tissue were decreased significantly; bone area of vertebrae, lumbar vertebrae, lumbosacral, pelvis was decreased significantly, the percentage of muscle tissue increased significantly, while the percent age of adipose tissue were decreased significantly; the percentage of muscle tissue in left pelvis and right pelvis increased significantly in OP medication group,while the percent age of adipose tissue were decreased significantly,with statistical significance (P<0.05 or P<0.01). Compared with normal control group, the content of bone mineral salt in the whole body of tree shrews (including head,excluding head),vertebrae and lumbar vertebrae decreased significantly in OPF model group,while the percent age of adipose tissue were increased significantly; the content of bone salt and the percentage of muscle tissue in pelvis decreased significantly, while the percent age of adipose tissue were increased significantly; the percent age of adipose tissue in lumbosacral,left pelvis and right pelvis increased significantly, with statistical significance (P<0.05 or P<0.01). Compared with OPF model group, the percent age of adipose tissue in the whole body of tree shrews (including head,excluding head), vertebrae and pelvis increased significantly in OPF medication group,while the percent age of adipose tissue were increased significantly; the percent age of adipose tissue in lumbar vertebra, lumbosacral, left pelvis and right pelvis decreased significantly,with statistical significance (P<0.05 or P<0.01). CONCLUSIONS: Osteoking can improve body composition of OP or OPF model tree shrews.
期刊: 2018年第29卷第18期
作者: 袁鑫,角建林,吴超,赵宏斌,郭玉倩,郑红,唐薇
AUTHORS: YUAN Xin,JIAO Jianlin,WU Chao,ZHAO Hongbin,GUO Yuqian,ZHENG Hong,TANG Wei
关键字: 恒古骨伤愈合剂;树鼩;骨质疏松;骨质疏松性骨折;体成分
KEYWORDS: Osteoking; Tree shrews; Osteoporosis; Osteoporotic fracture; Body composition
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