救必应胃痛片的HPLC指纹图谱研究
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篇名: 救必应胃痛片的HPLC指纹图谱研究
TITLE:
摘要: 目的:建立救必应胃痛片的指纹图谱,为完善其质量控制提供参考。方法:采用高效液相色谱法建立13批救必应胃痛片的指纹图谱,采用《中药指纹图谱相似度评价系统》(2012年版)对生成的指纹图谱进行分析,并以方中3种药材(木香、肉桂和陈皮)提取液为对照对各共有峰进行归属。结果:13批救必应胃痛片指纹图谱的相似度均大于0.952,共确定了12个共有色谱峰,并指认了其中3、4、10、12号共有色谱峰分别为橙皮苷、桂皮醛、木香烃内酯、去氢木香烃内酯。其中,2、3、5、8、9、11号共有色谱峰归属于陈皮药材,10、12号共有色谱峰归属于木香药材,1、4、6、7号共有色谱峰归属于肉桂药材。结论:本研究为救必应胃痛片的质量控制提供了一定的试验依据。
ABSTRACT: OBJECTIVE: To establish fingerprint for Jiubiying weitong tablets, and to provide reference for improving quality control of it. METHODS: The fingerprints for 13 batches of Jiubiying weitong tablets were established by HPLC. Similarity Evaluation System for Chromatographic Fingerprint of TCM (2012 edition) was used to analyze fingerprint. The attribution of common peaks were assigned by using 3 kinds of medicinal materials (Aucklandia lappa, Cinnamomum cassia and Citrus reticulata) extracts as reference. RESULTS: The similarity of 13 batches of Jiubiying weitong tablets was higher than 0.952, and 12 common chromatographic peaks were observed. No. 3, 4, 10 and 12 common chromatographic peaks were hesperidin, cinnamaldehyde, costuslactone and dehydrocostuslactone, respectively. No. 2, 3, 5, 8, 9, 11 common chromatographic peaks were attributed to C. reticulate; No. 10 and 12 common chromatographic peaks were attributed to A. lappa; No. 1, 4, 6, 7 common chromatographi peaks were attributed to C. cassia. CONCLUSIONS: The study provide certain evidence for quality control of Jiubiying weitong tablets.
期刊: 2018年第29卷第13期
作者: 蒋秋香,韦雪丹,莫海彦,黎理,蔡毅,马妍
AUTHORS: JIANG Qiuxiang,WEI Xuedan,MO Haiyan,LI Li,CAI Yi,MA Yan
关键字: 救必应胃痛片;高效液相色谱法;指纹图谱
KEYWORDS: Jiubiying weitong tablets; HPLC; Fingerprint
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