正交试验优化参芪妇康颗粒的提取工艺
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篇名: 正交试验优化参芪妇康颗粒的提取工艺
TITLE:
摘要: 目的:优化参芪妇康颗粒的提取工艺。方法:采用单因素法,以药材吸水率为指标考察第1次加水倍数,以干膏得率为指标考察药材浸泡时间;在单因素试验的基础上,采用加权综合评分法,以干膏得率和75%乙醇浸出物含量为指标,以提取时间、加水倍量、提取次数为因素,采用L9(34)正交表试验优化参芪妇康颗粒的水提工艺,并进行验证。结果:参芪妇康颗粒最优水提工艺为8倍水量(L/kg),提取 3 次,每次1 h。结论:优化的提取工艺操作稳定、质量可控,可为参芪妇康颗粒的工业化生产提供一定参考。
ABSTRACT: OBJECTIVE: To optimize extraction technology of Shenqi fukang granules. METHODS: Single factor method was used to investigate water multiple at first time using water absorption as index, soaking time using yield of dry extract as index. Based on single factor test, by weighted comprehensive scoring method, using the yield of dry extract and the content of 75% ethanol extraction as indexes, extraction time, water multiple and extraction times as factors, L9(34) orthogonal test was used to optimize water extraction technology of Shenqi fukang granules. Validation test was conducted. RESULTS: The optimal water extraction technology included 8-fold water (L/kg), extracting for 3 times, 1 h each time. CONCLUSIONS: The optimized extraction technology is stable and controllable in quality, and can provide reference for industrial production of Shenqi fukang granules.
期刊: 2018年第29卷第10期
作者: 孙臻,张影,汪杰,陈明聪,黄祖光,高华宏
AUTHORS: SUN Zhen,ZHANG Ying,WANG Jie,CHEN Mingcong,HUANG Zuguang,GAO Huahong
关键字: 参芪妇康颗粒;提取工艺;正交试验;干膏得率;乙醇浸出物含量
KEYWORDS: Shenqi fukang granules; Extraction technology; Orthogonal test; Yield of drug extract; Content of ethanol extract
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