抗菌药物耐药负担研究测算方法现状与分析
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篇名: 抗菌药物耐药负担研究测算方法现状与分析
TITLE:
摘要: 目的:了解抗菌药物耐药负担研究测算方法现状并进行分析,为我国开展抗菌药物耐药经济负担研究提供方法学文献支持。方法:计算机检索PubMed、ProQuest Health & Medical Complete、Springer等数据库,梳理相关研究并分析目前国外常用抗菌药物耐药负担测算方法以及注意事项。结果与结论:抗菌药物耐药负担一般通过耐药发生数(率)、耐药致死数、额外床日数以及耐药经济负担几个方面来衡量,在测算过程中需要注意研究角度的确定、结局指标的定义、感染前住院时间的控制、对照组的选择、疾病严重程度的调整及计算时间点、感染发生时间的计算、成本的界定以及耐药经济负担的计算范围。后续研究应该着眼于从全社会角度进行抗菌药物耐药负担的测算,为决策者进一步控制耐药发展提供可以参考的基线数据证据。
ABSTRACT: OBJECTIVE: To investigate and analyze the situation of measurement method for antimicrobial resistance (AMR) burden research, in order to provide methodology literature support for conducting AMR burden research in China. METHODS: Retrieved from PubMed, ProQuest Health & Medical Complete, Springer datebase, related researches were summarized, and foreign calculation method of resistance burden of commonly used antimicrobial and matters of attention were analyzed. RESULTS & CONCLUSIONS: AMR burden is usually evaluated using indicators like the number of resistant incidents, deaths due to AMR, excess length of stay and economic burden of AMR. The issues needed to be considered during calculating the burden included the perspective, definition of the outcome indicator, controlling the length of stay before infection, selection of control group, adjustment for severity of illness, time point calculation, calculation of onset time of infection, definition of the cost and scale of the economic burden. Future studies needs to be focused on a social perspective to estimate the burden of AMR, so as to provide baseline data evidence for decision makers to further control the resistance.
期刊: 2018年第29卷第9期
作者: 海沙尔江·吾守尔,魏国旭,管晓东,史录文
AUTHORS: Haishaerjiang·Wushouer,WEI Guoxu,GUAN Xiaodong,SHI Luwen
关键字: 抗菌药物;耐药负担;测算方法;现状
KEYWORDS: Antimicrobial agents; Burden of resistance; Measurement method; Situation
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