Box-Behnken设计-响应面法优化盐酸苯环壬酯透皮贴剂的处方
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篇名: Box-Behnken设计-响应面法优化盐酸苯环壬酯透皮贴剂的处方
TITLE:
摘要: 目的:优化盐酸苯环壬酯透皮贴剂的处方。方法:采用有机溶剂挥发法制备盐酸苯环壬酯透皮贴剂。以48 h的累积透皮量为指标,采用单因素试验和Box-Behnken设计-响应面法优化处方中投药量、透皮吸收促进剂氮酮用量、压敏胶用量,并对最优处方所制贴剂的外观和黏附力进行评价。结果:最优处方为投药量263 mg、氮酮165 mg、压敏胶1.94 g、甲醇1.6 g,所制贴剂的48 h累积透皮量为(119.48±2.95) μg/cm2(n=5),与预测值的相对误差为2.48%;其表面平整光洁、切口光滑,黏附力较好。结论:成功制得盐酸苯环壬酯透皮贴剂,其累积透皮量达到预期标准。
ABSTRACT: OBJECTIVE: To optimize the formulation of Phencynonate hydrochloride transdermal patch. METHODS: Phencynonate hydrochloride transdermal patch was prepared by solvent evaporation method. Using 48 h accumulative transdermal volume as index, single factor test and Box-Behnken design-response surface methodology were used to optimize drug dosage, the amount of transdermal enhancers azone and pressure-sensitive adhesive, and evaluate the appearance, adhesion of the formulation prepared by the best prescription. RESULTS: The optimized formulation was as follows as 263 mg drug dosage, 165 mg azone, 1.94 g pressure-sensitive adhesive and 1.6 g methanol. 48 h accumulative transdermal volume of prepared patch was (119.48±2.95) μg/cm2(n=5), related error of which to predicted value was 2.48%. The prepared patch showed smooth surface and incision, good adhesiveness. CONCLUSIONS: Phencynonate hydrochloride transdermal patch is prepared successfully, its accumulative transdermal volume is in agreement with predicted standard.
期刊: 2018年第29卷第7期
作者: 廖诗琴,刘辉,赵静,王彦辰,郭真君
AUTHORS: LIAO Shiqin,LIU Hui,ZHAO Jing,WANG Yanchen,GUO Zhenjun
关键字: 盐酸苯环壬酯;透皮贴剂;累积透皮量;Box-Behnken设计-响应面法;处方优化
KEYWORDS: Phencynonate hydrochloride; Transdermal patch; Accumulative transdermal volume; Box-Behnken design-response surface methodology; Formulation optimization
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