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注射用血塞通对MCA粥样硬化性血管狭窄伴MES阳性TIA患者MES和血脂水平的影响
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| 篇名： | 注射用血塞通对MCA粥样硬化性血管狭窄伴MES阳性TIA患者MES和血脂水平的影响 |
| TITLE： | |
| 摘要： | 目的： 探讨注射用血塞通对大脑中动脉（MCA）粥样硬化性血管狭窄伴微栓子（MES）阳性短暂性脑缺血发作（TIA）患者MES和血脂水平的影响。方法：选择2015年5月－2016年5月成都中医药大学附属医院收治的MCA粥样硬化性血管狭窄伴MES阳性TIA患者98例，按随机数字表法分为常规组和血塞通组，各49例。常规组患者给予常规治疗；血塞通组患者在常规组治疗的基础上给予注射用血塞通（冻干）400 mg，静脉滴注，每日1次，连用15 d。观察两组患者治疗前、治疗15 d及第3、6个月后MES各级分布情况和MES个数，治疗前及治疗15 d后三酰甘油、总胆固醇、低密度脂蛋白水平，记录缺血性事件及不良反应发生情况。结果：治疗15 d后，两组患者MES各级分布情况均显著优于同组治疗前，且血塞通组显著优于常规组，差异均有统计学意义（P＜0.05）。治疗第3、6个月后，血塞通组患者MES各级分布情况均显著优于同期常规组，且治疗后6个月显著优于治疗后3个月，差异均有统计学意义（P＜0.05）。治疗15 d及第3、6个月后，两组患者MES个数均显著少于同组治疗前，随时间延长逐渐减少，且血塞通组显著少于常规组，差异均有统计学意义（P＜0.05）。治疗15 d后，两组患者三酰甘油、总胆固醇水平均显著低于同组治疗前，且血栓通组显著低于常规组，差异均有统计学意义（P＜0.05）；治疗前后低密度脂蛋白水平比较，差异均无统计学意义（P＞0.05）。治疗第6个月后，常规组患者缺血性事件总发生率显著高于同组治疗第3个月后，血塞通组患者治疗第3、6个月后缺血性事件发生率均显著低于同期常规组，差异均有统计学意义（P＜0.05）。治疗第6个月后，两组患者不良反应发生率均显著低于同组治疗第3个月后，差异均有统计学意义（P＜0.05）。结论：在常规治疗的基础上加用注射用血塞通可减少MCA粥样硬化性血管狭窄伴MES阳性TIA患者的MES数量，降低缺血性事件发生率，进一步改善血脂水平，且未增加不良反应的发生。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Xuesaitong for injection on microembolic signal （MES） and blood lipid of patients with middle cerebral artery （MCA）atherosclerotic stenosis complicated with MES positive transient ischemic attack （TIA）. METHODS： A total of 98 patients with MCA atherosclerotic stenosis complicated with MES positive TIA in the Affiliated Hospital of Chengdu University of TCM during May 2015-May 2016 were divided into routine group and Xuesaitong group according to random numble table， with 49 cases in each group. Routine group received routine treatment. Xuesaitong group was additionally given Xuesaitong for injection （lyophilized） 400 mg intravenously， once a day， for consecutive 15 d， on the basis of routine treatment. The distribution of MES classification and the number of MES were observed in 2 groups before treatment， 15 d after treatment and 3rd and 6th month after treatment. The levels of TG， TC， LDL were observed before treatment and 15 d after treatment. The occurrence of ischemia event and ADR were recorded. RESULTS： Fifteen days after treatment， the distribution of MES classification in 2 groups was significantly better than before treatment； Xuesaitong group was significantly better than routine group， with statistical significance （P＜0.05）. At 3rd and 6th month after treatment， the distribution of MES classification in Xuesaitong group was significantly better than routine group； 6th month after treatment was significantly better than 3rd month after treatment， with statistical significance （P＜0.05）. Fifteen days and the 3rd， 6th month after treatment， the number of MES in 2 groups were significantly lower than before treatment and decreased as time； Xuesaitong group was significantly lower than routine group， with statistical significance （P＜0.05）. Fifteen days after treatment， TG and TC levels of 2 groups were significantly lower than before treatment； Xuesaitong group was significantly lower than routine group， with statistical significance （P＜0.05）； there was no statistical significance in the level of LDL before and after treatment （P＞0.05）. The incidence of ischemic events in routine group at 6th month after treatment was significantly higher than 3rd month after treatment， and the incidence of ischemic events in Xuesaitong group at 3rd and 6th month after treatment was significantly lower than routine group， with statistical significance （P＜0.05）. At 6th month after treatment， the incidence of ADR in 2 groups was significantly lower than 3rd month， with statistical significance （P＜0.05）. CONCLUSIONS： Based on routine treatment， Xuesaitong for injection can reduce the number of MES， reduce the incidence of ischemia events and further improve the level of blood lipid in patients with MCA atherosclerotic stenosis complicated with MES positive TIA without increasing the occurrence of ADR. |
| 期刊： | 2018年第29卷第4期 |
| 作者： | 史敏，杨东东，罗丹青，王倩男，宁金丽 |
| AUTHORS： | SHI Min，YANG Dongdong，LUO Danqing，WANG Qiannan，NING Jinli |
| 关键字： | 短暂性脑缺血发作； 微栓子；大脑中动脉；粥样硬化性血管狭窄；注射用血塞通；影响 |
| KEYWORDS： | Transient cerebral attack； Microembolic signal； Middle cerebral artery； Atherosclerotic angiostenosis； Xuesaitong for injection； Effects |
| 阅读数： | 268 次 |
| 本月下载数： | 2 次 |
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