中药安全研究的知识图谱与主题分析
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篇名: 中药安全研究的知识图谱与主题分析
TITLE:
摘要: 目的:了解中药安全领域的研究热点及相互关联,以促进中药质量改善、中药安全管理水平提升,推动中药安全问题的深入研究。方法:运用词频分析法,借助SATI 3.2软件和Ucinet 6软件,统计研究文献中与中药安全、质量及风险相关的关键词或主题词出现的频次。对高频关键词作共现分析,并以共现矩阵为基础绘制高频关键词的可视化网络图谱;从网络密度、集聚度、小世界效应3个方面进行关键词网络整体特征分析,从节点中心性、中间中心性和接近中心性3个方面进行网络个体特征分析,探讨研究主题热点及关联性。结果与结论:“中药饮片”“加工炮制”“中药质量”“质量管理”等为中药安全研究领域的主要问题和关键点;中药饮片是其中最主要的领域,其问题集中体现在中药加工炮制中;中药加工炮制的方法、工艺等对中药安全的影响显著。建议应树立质量观念,通过质量管理、质量标准建设、质量控制等手段来改善中药安全水平,降低中药安全风险,提升中药质量,并充分发挥《中国药典》的标准和规范作用。
ABSTRACT: OBJECTIVE: To investigate the research hotspots of TCM safety and their relationship, so as to promote the improvement of TCM quality, TCM safety management and further research of TCM safety. METHODS: The word frequency analysis was used to study the frequency of keywords and thematic words related to TCM safety, quality and risk in literatures with the help of SATI 3.2 and Ucinet 6 statistical software. The co-occurrence analysis of high frequency keywords was conducted, and visual network graph of high frequency keywords was drawn on the basis of co-occurrence matrix. The network general characteristics of keywords were analyzed in respects of network density, concentration degree and small-world effect. The network individual characteristics of keywords were analyzed in respects of node centrality, betweenness centrality and closeness centrality, so as to discuss the research thematic hotspots and relevance. RESULTS & CONCLUSIONS: “TCM decoction piece”“processing”“TCM quality”“quality management” were main issues and key points of TCM safety research; TCM decoction piece was the most important field, the problems of which mainly reflected in TCM processing. The method and technology of TCM processing influenced TCM safety significantly. It is suggested to establish view of quality, improve the level of TCM safety by means of quality management, quality standard construction and quality control, reduce the risk of TCM safety, improve TCM quality and fully play the role of standard and standardization of Chinese Pharmacopoeia.
期刊: 2018年第29卷第4期
作者: 张静,叶六奇
AUTHORS: ZHANG Jing,YE Liuqi
关键字: 中药;安全;质量;风险;主题;词频;知识图谱
KEYWORDS: TCM; Safety; Quality; Risk; Theme; Word frequency; Knowledge mapping
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