我院135例肺恶性肿瘤患者化疗致便秘的相关因素及防治方案的调查分析-中国药房

我院135例肺恶性肿瘤患者化疗致便秘的相关因素及防治方案的调查分析

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篇名：	我院135例肺恶性肿瘤患者化疗致便秘的相关因素及防治方案的调查分析
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摘要：	目的：为减少化疗导致的便秘发生和优化便秘治疗提供参考。方法：收集在我院呼吸科住院治疗的符合纳入标准的肺恶性肿瘤患者的病历资料，对患者的性别、年龄、便秘病史、肿瘤类型和分期、体力状况评分、生活习惯改变情况、化疗方案（包括辅助用药）以及便秘发生和防治情况等进行调查和统计、分析，考察化疗致便秘的相关因素。结果：共135例患者纳入本研究。135例患者中66例发生便秘，发生率为48.89％，其中96.97％为1、2级便秘。便秘发生与患者性别、年龄及生活习惯改变等均没有显著相关性（P＞0.05）；曾有便秘病史、肿瘤分期晚、每周期化疗天数≥3 d、使用帕洛诺司琼、联合使用阿瑞匹坦的患者便秘发生率显著增高（P＜0.05）。发生便秘的患者中有21.21％症状能自行缓解，有33.33％通过饮食调整症状可改善，有45.45％需要通过开塞露、乳果糖等药物治疗改善症状；其中有24.24％再次化疗时使用乳果糖预防便秘。结论：化疗导致的便秘发生率高，其发生与多种因素相关，但尚未引起医师和患者的足够重视，故需要临床药师在化疗过程中提供多方面的药学服务，并协助医师制订合理的便秘防治方案。
ABSTRACT：	OBJECTIVE： To provide reference for reducing the occurrence of chemotherapy-induced constipation and optimizing constipation therapy. METHODS： Medical records of malignant lung tumor inpatients meeting inclusion criteria were collected from respiration department of our hospital， and then investigated and analyzed statistically in respects of patient’s gender， age， constipation history， tumor types and phases， physical status score， living habit change， chemotherapy plan （including adjuvant drug）， constipation occurrence， prevention and treatment， etc. The related factors of chemotherapy-induced constipation were investigated. RESULTS： A total of 135 patients were enrolled in the investigation. Of 135 patients， 66 patients had constipation with incidence of 48.89％， among which 96.97％ were grade 1 and grade 2 constipation. The onset of constipation were independent from age， gender and living habit change （P＞0.05）. The patients with history of constipation， advanced tumor stage， the period of treatment≥3 days， the use of palonosetron and combined with aprepitant had higher prevalence of constipation （P＜0.05）. The clinical symptoms were improved spontaneously in 21.21％ patients， 33.33％ after diet adjustment and 45.45％ by drug treatment as suppositories glycerol， lactulose； 24.24％ patients used lactulose to prevent constipation at rehospitalization. CONCLUSIONS： Chemotherapy-induced constipation was commonly occurred and related to serval factors and had not got enough attention yet. The clinical pharmacists should assist the physicians to make individual chemotherapy regimen as well as the prevention of adverse drug reactions.
期刊：	2017年第28卷第30期
作者：	金知萍，许青，吕迁洲
AUTHORS：	JIN Zhiping，XU Qing，LYU Qianzhou
关键字：	肺恶性肿瘤；化疗；便秘；相关因素；防治方案
KEYWORDS：	Lung malignant tumor； Chemotherapy； Constipation； Related factor； Prevention and treatment plan
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