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比阿培南治疗急性细菌性感染的疗效及对患者血清IL-6和hs-CRP的影响
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| 篇名： | 比阿培南治疗急性细菌性感染的疗效及对患者血清IL-6和hs-CRP的影响 |
| TITLE： | |
| 摘要： | 目的：考察比阿培南治疗急性细菌性感染的临床疗效、细菌学疗效及对患者血清白细胞介素6（IL-6）、超敏C反应蛋白（hs-CRP）的影响。方法：选择2015年4月－2016年4月我院收治的呼吸系统和泌尿系统急性细菌性感染患者241例，按照随机数字表法分为对照组（119例）和观察组（122例）。对照组患者给予注射用美罗培南0.5 g加入100 mL 0.9％氯化钠注射液中静脉滴注，tid；观察组患者给予注射用比阿培南0.3 g加入100 mL 0.9％氯化钠注射液中静脉滴注，bid。两组患者疗程均为7～14 d。比较两组患者的临床疗效、细菌学疗效、血清IL-6和hs-CRP水平，以及不良反应发生情况。结果：对照组患者的总有效率、细菌培养阳性率、细菌清除率和不良反应发生率分别为88.24％、56.30％、87.14％和13.45％，观察组患者分别为93.44％、55.74％、93.06％和10.66％，两组比较差异均无统计学意义（P＞0.05）。治疗前，两组患者血清IL-6和hs-CRP水平比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者血清IL-6和hs-CRP水平均较治疗前显著降低，差异均有统计学意义（P＜0.05），但组间比较差异无统计学意义（P＞0.05）。结论：比阿培南治疗呼吸系统和泌尿系统急性细菌性感染的临床疗效和细菌学疗效均较好，能够明显降低机体炎症因子水平，且安全性较好。其有效性与安全性与美罗培南相当，应根据患者具体情况选择用药。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and bacteriological efficacy of biapenem in the treatment of acute bacterial infection， and its effects on serum IL-6 and hs-CRP levels. METHODS： A total of 241 patients with acute bacterial infection of respiratory system and urinary tract system selected from our hospital during Apr. 2015-Apr. 2016 were divided into control group （119 cases） and observation group （122 cases） according to random number table. Control group was given Meropenem for injection 0.5 g added into 100 mL 0.9％ NaCl injection intravenously， tid. Observation group was given Biapenem for injection 0.3 g added into 100 mL 0.9％ NaCl injection intravenously， bid. Treatment course of 2 groups lasted for 7-14 d. Clinical efficacies， bacteriological efficacies， serum interleukin-6 （IL-6） and hypersensitive C-reactive protein （hs-CRP） levels， the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate， bacterial culture positive rate， bacterial clearance rate and the incidence of ADR were 88.24％， 56.30％， 87.14％， 13.45％ in control group and 93.44％， 55.74％， 93.06％， 10.66％ in observation group， without statistical significance （P＞0.05）. Before treatment， there was no statistical significance in serum IL-6 or hs-CRP levels between 2 groups （P＞0.05）. Compared with before treatment， serum IL-6 and hs-CRP levels of 2 groups were decreased significantly after treatment， with statistical significance （P＜0.05）； there was no statistical significance between 2 groups （P＞0.05）. CONCLUSIONS： Biapenem in the treatment of acute bacterial infection of respiratory system and urinary tract system has excellent efficacy， and can significantly reduce inflammatory factor level with good safety. Response rate and safety of biapenem are similar to those of meropenem， so drugs should be selected according to specific condition of patients. |
| 期刊： | 2017年第28卷第29期 |
| 作者： | 孔珊珊，鞠文翠 |
| AUTHORS： | KONG Shanshan，JU Wencui |
| 关键字： | 比阿培南；美罗培南；急性细菌性感染；白细胞介素6；超敏C反应蛋白；疗效 |
| KEYWORDS： | Biapenem； Meropenem； Acute bacterial infection； Interleukin-6； Hypersensitive C-reactive protein； Curative effect |
| 阅读数： | 272 次 |
| 本月下载数： | 1 次 |
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